PPT-Normal Protein

T rafficking and the Unfolded Protein R esponse by Karen S Huffman Math and Science Department Genesee Community College Batavia NY National Center for Case Study Teaching in Science NORMAL PROTEIN TRAFFICKING. “Chubby Cheeks” . Dept. of Pediatric Gastroenterology. SGPGIMS, . Lucknow. Chubby cheeks – cute babies?. DIED !. ALIVE. Sep 2008 (3mo) Apr 2009 (10mo). Web: . pollev.com/. ucibio. Text: . To: 37607. . Type in: 169964 <your question>. The importance of structure. “Chaperones” & protein folding. Misfolded. proteins are very, very bad!. and intracellular accumulations. . Manar. . Hajeer. , MD, . FRCPath. . . AUTOPHAGY. auto, self; . phagy. , eating. A survival mechanism in times of nutrient deprivation. Involved in the clearance of . homocystinuria. (CBS deficiency). Andrew Morris. Homocysteine. formation is minimised by giving enough methionine for protein synthesis but not much more. This needs a . very. low-protein diet & supplements of the other amino acids. , and Miranda. Case study. A 15-year-old female comes in for her annual physical. Her mom informs you that she is worried because the girl has been on a strict diet and has lost a great deal of weight in the past few months. She has very little energy and does not seem interested in hanging out with her friends. The girl mentions that she has been losing some hair lately and she has not menstruated over three months. Microscopic analysis of her urine does not reveal anything abnormal.. Ophthalmic manifestation of congenital protein C deficiency Dr Shahla ansary peiatric heamatologyonclogist Dr Amir hesabi Assistant pediatric hematologyoncologist Case 1 CC: purpura fulminans 6a & b. Mutations. Learning Intentions. By the end of this topic you should be able to:. (a) Mutations. Define ‘mutation’ and describe the effect of one . (. b) Single gene mutation. Meiotic. G9 vs G22. 171 / 65. 11 / 16. S9 vs S22. 93 / 39. 2 / 9. S9 sel. 21 / 9. 0 / 2. G9 sel. 25 / 13. 1 / 3. G9 vs S9. 52 / 29. 5 / 7. S9 vs G9. 62 / 38. 8 / 9. S22 vs G22. 125 / 73. 53 / 17. G22 vs S22. C-reactive protein was originally discovered as a substance in the serum of patients with acute inflammation that react with the C polysaccharide of pneumococcus, this protein which cause the reaction is called CRP.. Enteropathy. MEDICAL GRANDROUNDS. Presented by: Genevieve L. . Collado. , MD. Moderator: Paolo P. Lorenzo, MD. To discuss the diagnostic approach to . hypoalbuminemia. with . anasarca. .. To present an unusual case of . Colleen H. Erb, MSN, CRNP ACNP-BC, AOCNP. Hematology/Oncology Nurse Practitioner – Drugs & Biologics Team. National Comprehensive Cancer Network. Important things to remember. DO NOT COMPARE YOUR RESULTS WITH ANOTHER PATIENT . KWWSVGRLRUJ%-1 3XEOLVKHGRQOLQHE\&DPEULGJH8QLYHUVLW\3UHVV not be affected by nutrition, but depends on the balance between the rates of synthesis and. catabolism or loss. However, also important is the relative. distribution between the intravascular and extravascular. compartments, as the concentration depends on the. Dr. . Manishi. . Tripathi. REVERSION. SUPPRESSION. . Informational . suppressors . Interaction . suppressors. Overproduction suppressors. Bypass suppressors. .. Physiological suppressors.