PPT-Orbitrap mass spectrometry, a high-confidence screening tool in biopharmaceutical product

David Horn Thermo Fisher Scientific San Jose CA Outline Challenges in the characterization of biopharmaceuticals Introduction to the new generation of Orbitrap TM mass spectrometers Confident intact antibody analysis using the Q . Keywords. :. Molecular . ion (M. +). Fragmentation. Starter:. Use mini wipe boards to brainstorm what you know about mass spectrometry. A: . Use . the molecular ion peak in an organic . molecule’s . Barrett-wilt. , . phd. UW Mass spectrometry/proteomics facility. MASS ANALYZERS AND IONIZATION METHODS. Central components of a mass spectrometer. Vacuum chamber. Ionization source. Mass analyzer/filter. PUMP How the magnetic sector mass spectrograph works: qvB = mv), B the magnetic field, m is the mass of the Classically, the speed of the ion, v, is related Objectives of the presentation. To get an appreciation of the role of . physics . in . our day to day living. Acquaint ourselves to a novel and . widely used . research tool: Mass Spectrometer. To . introduce the basic physics of mass . Jonathan A. Karty, Ph.D.. jkarty@indiana.edu. http://msf.chem.indiana.edu . Why Mass Spectrometry. Information is composition-specific. Very selective analytical technique. Most other . spectroscopies. UW Mass spectrometry/proteomics facility. MASS ANALYZERS AND IONIZATION METHODS. Central components of a mass spectrometer. Vacuum chamber. Ionization source. Mass analyzer/filter. Detector. T. o perform mass spectrometry two things are required: . Objectives of the presentation. To get an appreciation of the role of . physics . in . our day to day living. Acquaint ourselves to a novel and . widely used . research tool: Mass Spectrometer. To . introduce the basic physics of mass . Fenyő. Readings for Today. http://fenyolab.org/pi2019. Ion Source. Mass Analyzer. Detector. mass/charge. intensity. Mass spectrometry . Mass Analyzer 1. Frag-mentation. Detector. Ion Source. Mass Analyzer 2. Working Group I The Physical Science BasisRegional fact sheet -MountainsCommonregionalchangesThe freezing level height in mountain areas is projectedto rise and will alter snow and ice conditions high Lecture 1. 4/13/2017. Announcements. Homework 2.2 Additional Problems - Due. Quiz Today (after Announcements). 4/18 Lecture – will go back to rest of NMR (interpretation examples and instrumentation), then continue on Mass . &. Secondary. . ion. . mass. . spectrometry. (SIMS). L. Seda Mut 20970802 . Neslihan . Ötük. 20622809. Beytepe. Ankara. 12.04.2012. Outline. Historical Background of MS. . and. SIMS. What is M. and Andrew Gioe. Computation of Molecular Mass. Mass Spectrum is a plot of intensity as a function of mass-charge ratio, m/z. . Mass-charge ratio can be determined through accelerating an ion.. Conti. . André E. Lalonde AMS Laboratory and . Dept of . Physics and Earth Sciences. University of Ottawa. AMS . Analysis of . Uranium Isotopes. and Trace . Elements in UOC Samples. International Conference on Nuclear Security. SOP template 1 Revised: 06 /2019 MTD Standard Operating Procedure (SOP) This Standard Operating Procedure (SOP) describes basic chemical safety information for Mass Spectrometry (MS) . Prior to con