PPT-Thyroid Pathophysiology

Christy Dosiou MD MS Clinical Associate Professor Division of Endocrinology Stanford University School of Medicine Learning objectives Know the clinical implications of thyroid anatomy Describe thyroid hormone synthesis and regulation of thyroid function. Thyroid hormone regulates metabolism in both animals and humans Metabolism is determined by mea suring the amount of oxygen used by the body over a speci64257c amount of time If the measure ment is made at rest it is known as the basal metabolic rat www.thyroid.orgThyroid SurgeryQUESTIONS AND CONSIDERATIONSWhen thyroid surgery is recommended, patients should ask several questions regarding the surgery including:Are there other means of treatment? neoplasms. Thyroid Cancer accounts for 1.5% of all cancers. in the US. Six deaths per 1 million people occur annually.. The most common endocrine malignancy accounts for 95% of all endocrine cancers. Clinical Associate Professor - Division of Endocrinology. Stanford University School of Medicine. Learning objectives. Know the clinical implications of thyroid anatomy. Describe thyroid hormone synthesis and regulation of thyroid function. Control systems of the body. The . nervous system . : . working through nerve impulses, so it is a rapid control system.. 2) The hormonal, or endocrine system: . working through hormones in blood, so it is a slow control system.. The thyroid is made of multiple . acini. (follicles). Each spherical follicle is surrounded by a single layer of cells and filled with . pink- staining protein-. aceous. material called colloid. . . Hypothalamus releases TRH . Act on the pituitary gland to release TSH . TSH causes the thyroid gland to release the thyroid hormones (T. 3. and T. 4. ). TRH and TSH concentrations are inversely related to T. Dr. . Gary Mumaugh. Essentials of Endocrinology . Main function. : releases . hormones. to control cellular activities of target cells. Autocrine. . cells. : secrete substances that control their own function. II. Dr Ravindra Kumar. Director Research. Bihar Animal Sciences University. Patna. For UG Students. Mode of action of thyroxine. Not well understood. . important effect of T4 is stimulation of oxygen utilization, hence its also related with increased BMR.. . heart. . diseases. Prof. . J. . Hanáček. Pathophysiology. and . clinical. . aspects. . of. . mitral. . stenosis. Pathophysiology. and . clinical. . aspects. . of. . mitral. . regurgitation. sample?. Does . ultrasound . help . to differentiate . adenoma lesions from parathyroid carcinoma?. Parathyroid carcinoma . is rare. , representing. <. 1% . of . primary hyperparathyroidism . cases.. Dr . Hiren. . Patt. D.M.. (Endocrinology). Myxoedema. Coma. What is . Myxoedema. Coma?. Severe hypothyroidism. Slowing of functions of multiple organs . ร.ท. .นพ.วิศรุต การุญ. บุญญานันท์. รพ.ภูมิพลอดุลยเดช. 7-month-old boy. Fever, rhinorrhea 4 days. Dyspnea 2 days. HR 150 bpm, RR 52/min, BP 104/84 mmHg, . Dr.Lilianne. Haj Hassan. 29/3/2016. Thyroid carcinoma. Thyroid carcinoma is uncommon . Life time risk of being diagnosed with thyroid carcinoma is less than . 1% (less than 1.5% of all adult cancers).