PPT-Population genomics: Do we really need theory?

Fred Allendorf or Cant we answer all of our questions by just generating more data 1 For many decades empirical population genetics lagged far behind theory developed by Sewall Wright RA Fisher JBS Haldane etc. selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Recombination breakpoints. Family Inheritance. -----. Module . 11 . – . Association Genetics. Nicholas Wheeler & David Harry – Oregon State University. What is association genetics?. Association genetics is the process of identifying alleles that are disproportionately represented among individuals with different phenotypes. It is a population-based survey used to identify relationships between genetic markers and phenotypic traits. selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Goal: A systems-level understanding of genomes and gene regulation:. February 6, 2013. Howard K. . Koh. , MD, MPH. Assistant Secretary for Health . U.S. Department of Health and Human Services . Progress Review Overview. Summarize the burden of Cancer in the U.S. and the role of Genomics . Overview and Capabilities: . . High Throughput Sequencing Facility (HTSG). Functional Genomics M. ammalian Genotyping Core (MGC). Corbin Jones. Faculty Director. Piotr . Meiczkowski . Technologies . What is Structural Genomics ?. Is the process of high-. throughtput. determination of 3-D structures of Biological macromolecules. What is the Goal of Structural Genomics ?. Provision of enough structural templates to facilitate homology modeling of most proteins.. “. User facility. providing high-throughput DNA sequencing & analysis in support of DOE missions in alternative . energy. , . carbon cycling . & . bioremediation. .”. Opened in 1999. ~240 UC Employees. Genomics and Society Nature (2014) “ …disorders not readily explained by standard tests can sometimes be diagnosed through genome sequencing and analysis.” The Origin of “Genomics& One of the earliest discussions of population size was by T.R. Malthus in his essay. The Principle of Population as it Affects the Future . Improvement . of Society (1798), which was refined in his second essay in 1803. Malthus mainly examined . . Carl Pray. 1. Can advances in biology transform Asian agriculture? Challenges are large. Food production . Productivity growth . Crises – . Biological -Africa Swine Fever, corn stalk borer, fall armyworm, wheat rust. FRCPath. MFPH MSc (Epidemiology). Professor in Translational Cancer Genetics. , Institute of Cancer Research. NHS Consultant in Clinical Genetics . (Honorary), Royal Marsden NHS Foundation Trust. Consultant in Public Health Medicine . What . is . Functional. . Genomics?. RNA . Transcription/Gene. . Expression. Measuring Gene. . Expression. Microarrays. High-throughput. . Sequencing. Transcriptional. . Regulation. Transcription. Ian Green. Clinical Engagement and Education Business Manager. Strategy. Work undertaken by Genome One (part of the . Garvan. Institute). Work underway. Completion date . –. 17. th. , March 2017. Ravi Madduri. madduri@anl.gov. Joint work with Paul . Davé. , Lukasz . Lacinski. , Alex Rodriguez, . Dinanath. . Sulakhe. , Ryan Chard and Ian Foster. Globus Genomics is developed, operated, and supported by researchers, developers, and .