PPT-Computational personal genomics:

selection regulation epigenomics disease Manolis Kellis MIT Computer Science amp Artificial Intelligence Laboratory Broad Institute of MIT and Harvard Goal A systemslevel understanding of genomes and gene regulation. http://. uoregon.edu/~moursund/dave/index.htm. “Computational . thinking is a fundamental skill for everybody, not just for computer scientists. To reading, writing, and arithmetic, we should add computational thinking to every child’s analytical ability. Enrico Pontelli. Department of Computer Science. New Mexico State University. The buzzword…. “Computational Thinking” . The thought processes involved in formulating problems and their solutions so that the solutions are represented in a form that can be effectively carried out by an information processing agent [Wing-. NHGRI strategic plan. What does the NIH think genomics should be for the next 10 years?. [Nature, Feb. 2011]. The Essence of Genomics. (according to NHGRI). Comprehensiveness. . Genomics . aims to generate complete data sets. Although relatively easy to define and measure for a genome sequence, attaining comprehensiveness can be more challenging for other targets (for example, functional genomic elements or the ‘proteome’). Class Overview. web site: www.cs.vt.edu/~kafura/CS6604. Origins. Term first used by Seymour . Papert. (1996) . [Snow 2012]. “. In . both . cases the computer used as a tool effectively . leads . to a solution, but in neither does the . NRC Report on Nature/Scope of CT. web site: www.cs.vt.edu/~kafura/CS6604. NRC Report. Sponsored by National Research Council. First of two reports. Not intended to produce or reflect a consensus among participants. Bioinformatics and Genomics. Applications:. Personalized cancer medicines. Disease determination . Pathway Analysis. Biomarker Discovery . An Interesting Point. “One . article estimated that the output from genomics may soon dwarf data heavyweights such as . selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Recombination breakpoints. Family Inheritance. Authors: Kyu . Han . Koh et. al.. Presented . by : . Ali Anwar. ABOUT ME. B.Sc. Electrical Engineering, University of Engineering and Technology Lahore, Pakistan. M.Sc. Computer Engineering. , University of Engineering and Technology Lahore, . 2012-2017. A Public Health Stakeholder Consultation. Co-Authors. Toby . Citrin. , JD. tcitrin@umich.edu. Center for Public Health and Community Genomics. Stephen M. . Modell. , MD, MS. mod@umich.edu. July 201 MaeÕr ddogfen yma hefyd ar gael yn Gymraeg. This document is also available in Welsh. #$%&'!#%()$*+,-./!01232! 1 Genomics for Precision Medicine Strategy Executive Summary New genetic and g Genomics and Society Nature (2014) “ …disorders not readily explained by standard tests can sometimes be diagnosed through genome sequencing and analysis.” The Origin of “Genomics& Bionano Genomics, San Diego, California, United States of America. Abstract. Pat Lynch, PhD. Background. Generating high-quality finished genomes replete with accurate identification of structural variation and high completion (minimal gaps) remains challenging using short read sequencing technologies alone. The . What . is . Functional. . Genomics?. RNA . Transcription/Gene. . Expression. Measuring Gene. . Expression. Microarrays. High-throughput. . Sequencing. Transcriptional. . Regulation. Transcription. Ravi Madduri. madduri@anl.gov. Joint work with Paul . Davé. , Lukasz . Lacinski. , Alex Rodriguez, . Dinanath. . Sulakhe. , Ryan Chard and Ian Foster. Globus Genomics is developed, operated, and supported by researchers, developers, and .