CLINICAL PROBABILITY AND - PowerPoint Presentation

Slide1

CLINICAL PROBABILITY AND DOPPLER ULTRASOUND IN DEEP VENOUS THROMBOSIS

M. BOUSSALAH (1), H. NAJIH (2), N. TOUIL(1), O. KACIMI (1), N. CHIKHAOUI (1), R. HABBAL (2)(1) Emergency Radiology service, Ibn Roch University Hospital,(2) Cardiology Department, Ibn Roch University Hospital, Casablanca, Morroco

VARIOUS

:

VR

18

Slide2

Clinical assessment is a fundamental step in the diagnostic workup of patients with suspected deep venous thrombosis (DVT). Although the diagnostic yield

of individual symptoms, signs, and common laboratory tests are limited, the combination of these variables can be used to express a clinical probability of DVT.It is important to asses it because treatment must be undertaken rapidly to avoid potentially fatal pulmonary embolism [1].Based

on history and physical examination for predicting the probability of deep venous

thrombosis, clinical scores were developed and improved the efficiency of early detection [2, 3].

INTRODUCTION :

VARIOUS : VR 18

2

Slide3

Prospective study during 10 March 2010 to 10 April 2011,Including 124 patients admitted in the emergency department with clinical supposition of lower extremity DVT,

The Wells score (Table. 1) was calculated : high probability of DVT if the score is >3 points; moderate probability if the score is 1 or 2 points;

low

probability if <0 points,POPULATION AND METHODS :VARIOUS : VR

183

Slide4

An ultrasound examination was performed in all cases, using : 3-5 MHz convex transductor (for iliac veins) and 7.5 MHz linear transductor (from femoral level to distal).Finding for DVT diagnosis were considered to be the following :identification of a thrombus (with different degrees of echogenicity depending upon the moment of formation,lack

of compressibility of the vein,distension of the recent thrombosed vein.POPULATION AND METHODS :VARIOUS : VR 18

4

Slide5

Doppler finding included :decreased flow augmentation proximal to the occlusive thrombus,continuous flow distal to the affected

vein,absence or diminution of Valsalva response.By color flow in non-occlusive thrombus, the blood flow around the thrombus was analyzed. In vein occlusion, the collateral tiny channels adjacent to the vein wall was searched.The statistical method use SPSS 16.0 vr F; P < 0.05 was considered significant statistically.

POPULATION AND METHODS :

VARIOUS : VR 185

Slide6

POPULATION AND METHODS :Clinical situation Points

Active cancer (treatment ongoing, or palliative within 6 months)+1Paralysis or recent plaster immobilization of the lower extremities

+1

Recently bedridden for >3 days or major surgery <4 week

+1

Localized tenderness along the distribution of the DV

+1

Entire leg swelling

+1

Calf swelling >3 cm compared to the asymptomatic

l

eg

+1

Pitting edema in the symptomatic leg

+1

Previous deep venous thrombosis documented

+1

Collateral superficial veins (non varicose)

+1

Alternative diagnosis (at least as likely that of

venous thrombosis)-2

Table. 1 : Wells score [2].

VARIOUS : VR 18

6

Slide7

Mean age : 49 years oldDeviation standard : 17Sex distribution

: 42 men and 82 women (fig. 1), sex ratio male/female: 0.51RESULTS : EPIDEMIOLOGYFig. 1 : Distribution of the patients

based

upon sex.VARIOUS : VR 187

Slide8

RESULTS : EPIDEMIOLOGYFig. 2 : The distribution of the patients based upon âge decade

VARIOUS : VR 188

Slide9

The patients present clinical signs of DVT :Unilateral pitting oedema found in 54.8%Calf pain and

tenderness : 62% Phlegmasia alba dolens : 1% Phlegmasia caerulea dolens : 1% .

The

DVT was confirmed in : 64.51% (80 patients)Right lower limb : 28.2% ,Left lower limb : 27.41%,Both lower limb : 7.25%.

Lower limb DVT

localization :Proximal : 30.64%, Distal : 9.6%,

Total : 24.2%.

RESULTS : CLINICAL PRESENTATION

VARIOUS

:

VR

18

9

Slide10

RESULTS : WELLS SCOREBased upon Wells score results the patients were divided into 3 groups (Fig. 3) :

First group – Low Probability: 26 patients,Second group – Moderate probability : 42 patients,Third group – High probability : 56 patients.Fig. 3: Distribution of the patients based upon Wells Score.VARIOUS : VR 1810

Slide11

RESULTS : DOPPLER USDoppler ultrasound examination was performed in all cases (Fig. 4) : Diagnosis of DVT : 80 patients,

Normal : 44 patients.Fig. 4: Distribution of doppler ultrasound finding in our study.VARIOUS : VR 1811

Slide12

RESULTS : DOPPLER US VERSUS WELLS SCOREFig. 5 : Clinical probability, based on Wells Score, confronted to dopller US finding in our study.

VARIOUS : VR 1812

Slide13

RESULTS : DOPPLER US VERSUS WELLS SCORESignificant difference regarding the DVT diagnosis was found :

Third - second group : P = 0,0005Second - first group : P = 0,0001VARIOUS : VR 1813

Slide14

DVT is the formation of a blood clot within a deep vein, and occurs about 1/1000 per year [4].It may occur in upper limb veins including the subclavian vein, visceral veins or the vena cava. More commonly, it occurs in the deep veins of the lower leg or the proximal veins of the

ilio-femoral segment.It is associated with a risk of pulmonary embolism (PE), making it potentially dangerous and an immediate diagnosis essential.The diagnosis or reliable exclusion of DVT is a daily task for clinicians. Yet, the approach used is often not standardized and sometimes lacks effectiveness and accuracy due to the wide range of possible tests,

the heterogeneity

of the various tests available, and the different experiences of physicians requesting or performing these examinations.DISCUSSION : DVT

VARIOUS : VR 18

14

Slide15

Clinical examination :Its clinical symptoms can include leg swelling, pain, and erythema, which result from outflow obstruction and venous wall inflammation.It, however, varies from minimal symptoms to massive features, and it is commonly believed that this variability is unreliable in predicting the diagnosis of DVT in patients with leg symptoms, leading to a large number of negative studies with venous duplex scanning [

5].Thus, physical examination alone is not sufficient and should be followed by more sensitive and specific testing.DIAGNOSIS PROCEDURESVARIOUS : VR 18

15

Slide16

Pretest probability scores :Recently, clinical assessment in the form of scoring systems, while unable to exclude or confirm the presence of DVT, has gained favor as a method of stratifying pretest probability [6, 7

].The best-known clinical scoring system was developed by Wells et al. and has been validated by other authors [8]. This scoring system assigns a numeric score to patients based on certain set of validation DVT risk factors (Table. 1).Patients are determined to be at low, moderate or high risk.The incidence of DVT in these groups ranges from 3% to 13%, 17%

to 38

%, and 60% to 75%, respectively, also, the difference in prevalence of DVT in the three categories was statistically significant [5,9].

DIAGNOSIS

PROCEDURES

VARIOUS : VR 18

16

Slide17

Pretest probability scores :In 2003, Wells et al. published a lightly different score wish again included previously documented DVT and divided patients into only two groups, one in wish DVT was likely (score > 2) and one in wish it was unlikely (score < 2) [

4].Our study agreed with the literature on pretest probability of the DVT, by demonstrating the the Wells score was useful in estimating the probability of DVT.DIAGNOSIS PROCEDURES

VARIOUS : VR 18

17

Slide18

D-dimer test :D-dimer is a degradation product of cross-linked fibrin, and elevated levels indicate fibrinolysis.Increased D-dimer are marker of thromboembolic events, however, its specificity is low.Different D-dimer tests are available and all assays vary in performance

characteristics [4]. The importance of D-dimer testing lies in the negative predictive value. Normal values effectively rule out PE. The negative predictive value for suspected DVT is lower than for PE, but in connection with pretest probability scores extensively evaluated

[

4].DIAGNOSIS PROCEDURES

VARIOUS : VR 18

18

Slide19

Ultrasound examination :When the measurement of the D-dimers cannot be performed, Doppler US represents the test of choice for the confirmation of

DVT diagnosis [10].Several studies have reported a sensitivity of 95% and specificity of 98% of this method for the DVT diagnosis, especially for proximal thrombosis [11].

The

overall sensitivity of ultrasound is considered to be between 86-98% [10]. Ultrasound is less sensitive in patients with

distal DVT; a negative ultrasound does not rule out the

diagnosis of DVT at this level.

DIAGNOSIS

PROCEDURES

VARIOUS : VR 18

19

Slide20

Ultrasound examination :In the absence of DVT, the veins collapse with a complete apposition of the vein walls during gentle compression. The loss of this property is the principal criterion

for the diagnosis of DVT.According to several studies, patients with a high probability of DVT have over a 75% prevalence of DVT confirmed by tests [9].We obtained similar results in our study in cases with a high probability : 64.5% patients with high probability had a confirmed

DVT

.DIAGNOSIS PROCEDURESVARIOUS : VR 18

20

Slide21

Others procedures :The venography is still the gold standard. However, radiation, contrast media, and the painful injection in pedal veins are limiting factors [4]. Spiral CT venography has been shown to have a sensitivity and specificity similar to that of conventional venography. However, costs and high radiation are limiting factors for the routine use of venous imaging [

4].Recent studies show a high sensitivity and specificity for MR venography, but its high costs and limited availability exclude it from routine use [4, 12]. DIAGNOSIS PROCEDURESVARIOUS : VR 18

21

Slide22

As an initial step in the diagnosis of DVT, the pretest probability score is recommended using the defined protocols.The patients should undergo either ultrasound or D-dimer testing (using a D-dimer test with a high sensitivity) [4].

Subsequent steps should depend on the outcome of the pretest probability evaluation and the results.Diagnosis strategiesVARIOUS : VR 1822

Slide23

Diagnosis strategiesVARIOUS : VR 1823

Fig. 6 : Proposed strategy for patients with suspected deep vein thrombosis (DVT). [5] Non-high clinical score: low or

moderate clinical score; PCP, pretest

clinical probability.

Slide24

Lindblad B, Sternby NH, Bergqvist D. Incidence of venous thromboembolism

verified by necropsy over 30 years.BMJ 1991; 302: 709-11.Wells PS, Hirsh J, Anderson DR, Lensing AW, Foster G, Kearon

C, et

al.Accuracy of clinical assessment of deep-vein thrombosis.Lancet

1995; 345:1326-30

Constans J, Boutinet C, Salmi L.R,

Saby

J.C

,

Nelzy

M.L

,

Baudouin P

, et al.

Comparison

of four

clinical

prediction scores for the diagnosis of lower limb deep venous thrombosis in outpatients.Am J Med 2003; 115: 436-40Beyer J, Schellong S, Deep vein thrombosis: Current diagnosis strategy. European

Journal of Internal Medicine

2005; 16 : 238-246.

Ymaki

T, Nozaki M, Sakurai H, Takeuchi M,

Soejima

K,

Kono

T, Prospective Evaluation of a Screening

Protocol to

Exclude Deep Vein Thrombosis on the Basis

of a

Combination of Quantitative D-Dimer

Testing and

Pretest Clinical Probability Score. J Am

Coll

Surg

; 2005; 201:1: 701-709.

Zhu L, Guo X, Wang J, Guo Y, Wang C, Ma H, Guo Y,

Comparison of four clinical scores for the predicting lower limb

deep venous

thrombosis in Chinese patients

Journal

of Nanjing

Medical

University

, 2008, 22(4):

230-233

REFERENCES :

VARIOUS : VR 18

24

Slide25

Delluc A, Le Pape F, Le Bras A, Gagne P, Taton G, Jaffrelot M, Le Duff N, Bressollette L, Le Gal G, Validation d’un score de prédiction clinique de la thrombose veineuse profonde des membres inférieurs spécifique à la médecine générale. Rev

Med Interne (2012), doi:10.1016/j.revmed.2011.12.004 Ambid-Lacombe C, Cambou JP, Bataille V, Baudoin D, Vassal-Hebrard B, Boccalon H, Bura Rivière A, Excellentes performances du score de Wells et du score de Wells modifié dans le diagnostic de thrombose veineuse profonde proximale ou distale chez des patients hospitalisés ou ambulatoires au CHU de Toulouse : étude TVP-PREDICT. Journal des Maladies Vasculaires 2009; 34 : 211—217

.

Tracy JA, Edlow JA, Ultrasound diagnosis of deep venous thrombosis. Emerg

Med Clin N Am 22 (2004)

775–796.Hotoleanu C, Fodor D, Suciu O, Correlations between clinical probability and Doppler

ultrasound results

in the assessment of deep venous thrombosis, Medical

Ultrasonography; 2010,;12; 1: 17-21.

Segal

JB

,

Eng

J,

Tamariz

LJ

, Bass

EB

. Review of the

evidence on diagnosis of deep venous thrombosis and pulmonary embolism. Ann Fam Med 2007; 5: 63-7. Evans AJ, Sostman HD, Knelson MH, Spritzer CE, Newman GE, Paine SS, et al. 1992 ARRS Executive Council Award. Detection of deep venous

thrombosis: prospective comparison of MR

imaging with

contrast

venography

. Am J

Roentgenol

1993;161(1):131–9 (

Jul

).

REFERENCES :

VARIOUS : VR 18

25

Slide26

CONCLUSION :The clinical diagnosis of deep venous thrombosis, which has been viewed as a clinical challenge for many years, has been improved through the use of the standardized assessment of the clinical probability of deep venous thrombosis before performing a diagnostic test

.Thus, the combination of pretest probability with non-invasive diagnostic test results simplifies and improves the diagnostic process in patients with suspected low extremity deep-vein thrombosis, and will decrease costs.Us showed in our study, a significant correlation between the clinical probability of deep venous thrombosis and

the

proportion of cases confirmed by doppler ultrasound.VARIOUS : VR 18

26

Slide27

Objectives : Deep Venous Thrombosis (DVT) is associated with a significant morbidity and mortality. Its diagnosis is based on clinical examination and complementary investigation, especially Doppler ultrasound. We aim to establish the correlation between the clinical probabilities of DVT based on Wells score and the results of Doppler ultrasound exam.

Materials and methods : We describe findings in a 124 patients with clinical supposition of DVT divided into 3 groups based upon the probability of DVT (Wells score): low, moderate and high, respectively. All the patients were examined by Doppler ultrasonography.  ABSTRACT :VARIOUS : VR 18

27

Slide28

Results : The DVT was confirmed by Doppler ultrasonography in more than half of the cases; the highest percent of confirmed cases were in the patients with a high probability of DVT (64, 5%) whereas the lowest percent was associated with the low clinical probability (20%). There was a significant difference regarding the

DVT diagnosis between third and the second group (p= 0, 0005), also between the second and the first group (p= 0, 0001).Conclusion : In the diagnosis of deep venous thrombosis, an exhaustive doppler ultrasound exam is necessary when the clinical probability is high, based on the Wells score. A significant correlation between the clinical probability of DVT and the proportion of cases confirmed by ultrasound, was demonstrated in this study.ABSTRACT :

VARIOUS

: VR 1828