PPT-Antiviral activity of fluorinated compounds against DNA- and RNA-containing viruses

Krystyna Naumenko 1 Polina Zaremba 1 Svitlana Zagorodnya 1 Serhii Siryi 2 Yaroslav Borodkin 2 Yurii Shermolovych 2 1 Zabolotny Institute of Microbiology and Virology National Academy of Sciences of Ukraine Acad . Viruses . A nonliving (?) particle made of proteins, nucleic acids, and sometimes lipids (fats). Viruses only reproduce by infecting living cells. Most viruses can only be seen with an electron microscope. Size of genome. Segmented or not. Site of replication.  . FAMILIES of NEGATIVE STRAND VIRUSES.  . NON-SEGMENTED (-)STRAND VIRUSES. .  . RHABDOVIRIDAE. Rabies, VSV, & Plant viruses .  . FILOVIRIDAE. Virus Characteristics. A virus is an infectious agent found in virtually all life forms.. Viruses consist of genetic material, and have a central core either DNA nor RNA. Although they are infectious agents, they differ from bacteria in that they contain . Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. Viral Chemotherapy. Difficult. . The genome . of the infecting virus is replicated so that . viral transcription . can be amplified and to provide copies . of the . genome for progeny . virions. .. Generally, DNA viruses copy their genomes . 4.4. Lesson Objectives:. After finishing today’s lesson, you will be able to. :. explain . how viral replication leads to host cell . lysis. .. describe . the replication of DNA and RNA viruses. .. Pass through specially designed filters. . In 1935, W.M Stanley – isolated TM V – find properties of a crystalline solid . . . Virus not a simply protein but nucleoprotein . Its infectious principle is the nucleic acid (RNA/DNA). Transcription, translation and transport. Transcription of virus genome. In the summary of the scheme depicted . below, most . of the nucleic acid strands are . labelled. (+) . or (. −). This . labelling. Transcription, translation and transport. Transcription of virus genome. In the summary of the scheme depicted . below, most . of the nucleic acid strands are . labelled. (+) . or (. −). This . labelling. Singh B, Huang H, Morton DP, Johnson GP, Gutfraind A, Galvani AP, et al. Optimizing Distribution of Pandemic Influenza Antiviral Drugs. Emerg Infect Dis. 2015;21(2):251-258. https://doi.org/10.3201/eid2102.141024. Viruses consist of a genome and sometimes a few enzymes stored in a capsule made of protein (called a . capsid. ), and sometimes covered with a lipid layer (sometimes called an 'envelope'). They are . Switch to ATV/r-. containing. . regimen. ATAZIP. Switch to ATV ± r-containing . regimen. SWAN . Study. SLOAT . Study. Switch . to ATV-. containing. . regimen. ARIES . Study. INDUMA . Study. ASSURE . 1- Former member of the . Papovaviridae. family. Similar to . polyomaviruses. in some respects, but with a larger genome (8 . kbp. ) and particle size (55 nm). . 2-There are many genotypes of human papillomaviruses, also known as . Background. Seasonal influenza is estimated to cause approximately 300,000 to 650,000 deaths worldwide annually. Currently, recommended antiviral agents for influenza (. oseltamivir. ) have not been studied in placebo controlled randomised trials to demonstrate survival benefit in hospitalized patients with influenza.