PPT-Lec . 8 Virus genome replication

The genome of the infecting virus is replicated so that viral transcription can be amplified and to provide copies of the genome for progeny virions Generally DNA viruses copy their genomes . . Gene therapy: . to correct a . genetic defect . by transferring of a . functional normal copy. of the gene into cells. Examples of diseases caused by genetic defect. Ornithine . transcarbamylase. to correct a . genetic defect . by transferring of a . functional normal copy. of the gene into cells. Examples of diseases caused by genetic defect. Ornithine . transcarbamylase. (OTC deficiency). In order to survive, viruses must be able to do the following:. 1. Find a host cell it can replicate in. 2. Bind to that cell. 3. Enter the cell. 4. Release its genome in order to replicate. 5. Replicate its genome. Genome: the total number of genes in an individual.. Human Genome- approx. 20,000 genes on the 46 human chromosomes.. Human Genome Project (HGP). Ongoing effort to completely map and sequence our genome.. Sadia. . Anjum. Virology lecture 5. 1. RNA VIRUS STRATEGIES. 2. RNA -> RNA. RNA-dependent RNA polymerase . RNA -> DNA. RNA-dependent DNA polymerase. - reverse transcriptase . Host cell DNA -> RNA. Size of genome. Segmented or not. Site of replication.  . FAMILIES of NEGATIVE STRAND VIRUSES.  . NON-SEGMENTED (-)STRAND VIRUSES. .  . RHABDOVIRIDAE. Rabies, VSV, & Plant viruses .  . FILOVIRIDAE.  . Author: Michael Fenech. Affiliation: Genome Health Foundation, North Brighton, SA, 5048, Australia. Email: . mf.ghf@outlook.com. . Introduction. Life as we know it depends entirely on the capacity of cells to utilize energy and molecules in the environment for cellular function and reproduction. . Authority. : International Committee on Taxonomy of . Viruses.. . http. ://. www.ictvdb.org/index.htm. Taxonomic . groups: Order. Family. Subfamily. In . their 1953 announcement of a double helix structure for DNA, Watson and Crick stated, . "It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.". Carcinogenesis. Carcinogenesis or . Oncogenesis. =. creation of cancer= normal cells are transformed into cancer cells= characterized by . a progression of changes on cellular and genetic level . that ultimately reprogram a cell to undergo uncontrolled cell division, thus forming a malignant mass..  . Antigenic drift. . where individual bases in the DNA or RNA . mutate. to other bases. Most of these . point mutations. are "silent" – they do not change the protein that the gene encodes. . . Outside . their host cells, viruses survive as . virus particles. , also known as . virions. . The . virion. is a . gene delivery . system; it contains the virus genome, and . its functions . are to protect the genome and to aid its . G-OnRamp Beta Users Workshop. Wilson Leung. 07/2016. Outline. Obtain genome assemblies from NCBI. Transfer . large genomics datasets to Galaxy. Common bioinformatics file formats . D. atatypes in Galaxy. Introduction:. Viral infections of plants can cause necrosis, hypoplasia . or . hyperplasia and these effects can lead to symptoms such as. Growth retardation . Distortion. Mosaic patterning of leaves.