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Identification  and assessment of new psychoactive substances: a European Identification  and assessment of new psychoactive substances: a European

Identification and assessment of new psychoactive substances: a European - PowerPoint Presentation

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Identification and assessment of new psychoactive substances: a European - PPT Presentation

network HOME2014JDRUAGDRUG7086 WS 3 Monitoring extent and patterns of use of NPS 28022016 1 4 Partners 2 Associate Partners Istituto di Ricerche Farmacologiche Mario Negri IRFMN Italy ID: 805975

nps activity wastewater 2016 activity nps 2016 wastewater ws1 uji irfmn analysis analytical cities reference extent markers standards methods

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Identification and assessment of new psychoactive substances: a European networkHOME/2014/JDRU/AG/DRUG/7086

WS 3Monitoring extent and patterns of use of NPS

28/02/2016

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4 Partners +2 Associate PartnersIstituto di Ricerche Farmacologiche Mario Negri (IRFMN), ItalyUniversitat Jaume I de Castellon (UJI), SpainFacultade de Farmacia, Universitade de Lisboa (FFULIS), PortugalIstituto Nacional de Medicina Legal e Ciencias Forenses (INMLFC), Portugal

Norsk Institutt for vannforskning (NIVA), NorwayEgas Monitz - Cooperativa de Ensino Superior (EMCES), Portugal

28/02/2016

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3 pillars of the projectIdentificationAssessment NPS“Quantification”Title: Monitoring extent and patterns of use of NPS (Monitoring the most widely-used NPS in European cities)Activities: The NPS identified and selected in WS1 and WS2 will be monitored in wastewater and urineAim: Assess NPS extent and pattern of use in the population by combining wastewater analysis and urine analysis in cities in Europe

28/02/2016

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Gantt - time table 

Months

Activities

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1415161718192021222324WS0 WS1 - activity 1                        WS1 - activity 2a                        WS1 - activity 2b                        WS1 - activity 3a                        WS1 - activity 3b                        WS1 - activity 3c                        WS2                        WS3 - activity 1                        WS3 - activity 2                        WS3 - activity 3                        

28/02/2016

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WS 3 : Monitoring extent and pattern of use of NPSActivity 1: synthesis of standard and metabolites (UJI, FFULISBOA) - Purchase of reference standard Reference standards already available (in IRFMN, …others ?) Reference standards commercially available

- Synthesis of standard, metabolites and deuterated analogues (identified and refined in WS1 and WS2) - Description of analytical parameters (retention time, isotopic distribution, fragment ions, fragmentation)Aim: to get reference standards and analytical parameters to set up analytical methods (activity 2)

28/02/2016

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WS3Activity 2: analytical methods in wastewater (IRFMN, UJI, FFULISBOA, INMLCF, EMCES, NIVA) Development, validation and standardization of analytical methods for NPS markers in wastewater Inter-laboratory standardization ? 28/02/2016

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WS3Activity 3. analysis of NPS markers in wastewater (IRFMN, UJI, NIVA…….) Analysis for markers in wastewater from EU cities (20 EU cities are foreseen 2016 or 2017 European SCORE study ? Ask for permission to the partners ?) and music festivals (urine and wastewater in 2017 ? ) Repeated sampling in some cities (Milan, Lisbon…..)

Enantiomeric profiling studiesActivity 4: estimating NPS use in Europe (IRFMN, UJI, FFULISBOA, INMLCF, EMCES, NIVA) Estimation of NPS use, trends and pattern of consumption (from analysis of markers in wastewater and in urine)

28/02/2016

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Expected resultsIdentification, assessment and quantification of some of the NPS most widely used in EuropeOutputs:A collection of about 100 substances (Standards, metabolites...)2 Research papers2 book chapters Meeting/Postgraduate Course (2 events)

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