network HOME2014JDRUAGDRUG7086 WS 3 Monitoring extent and patterns of use of NPS 28022016 1 4 Partners 2 Associate Partners Istituto di Ricerche Farmacologiche Mario Negri IRFMN Italy ID: 805975
Download The PPT/PDF document "Identification and assessment of new ps..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Identification and assessment of new psychoactive substances: a European networkHOME/2014/JDRU/AG/DRUG/7086
WS 3Monitoring extent and patterns of use of NPS
28/02/2016
1
Slide24 Partners +2 Associate PartnersIstituto di Ricerche Farmacologiche Mario Negri (IRFMN), ItalyUniversitat Jaume I de Castellon (UJI), SpainFacultade de Farmacia, Universitade de Lisboa (FFULIS), PortugalIstituto Nacional de Medicina Legal e Ciencias Forenses (INMLFC), Portugal
Norsk Institutt for vannforskning (NIVA), NorwayEgas Monitz - Cooperativa de Ensino Superior (EMCES), Portugal
28/02/2016
2
Slide33 pillars of the projectIdentificationAssessment NPS“Quantification”Title: Monitoring extent and patterns of use of NPS (Monitoring the most widely-used NPS in European cities)Activities: The NPS identified and selected in WS1 and WS2 will be monitored in wastewater and urineAim: Assess NPS extent and pattern of use in the population by combining wastewater analysis and urine analysis in cities in Europe
28/02/2016
3
Slide4Gantt - time table
Months
Activities
1
2
3
4
5
6
7
8
9
10
11
12
13
1415161718192021222324WS0 WS1 - activity 1 WS1 - activity 2a WS1 - activity 2b WS1 - activity 3a WS1 - activity 3b WS1 - activity 3c WS2 WS3 - activity 1 WS3 - activity 2 WS3 - activity 3
28/02/2016
4
Slide5WS 3 : Monitoring extent and pattern of use of NPSActivity 1: synthesis of standard and metabolites (UJI, FFULISBOA) - Purchase of reference standard Reference standards already available (in IRFMN, …others ?) Reference standards commercially available
- Synthesis of standard, metabolites and deuterated analogues (identified and refined in WS1 and WS2) - Description of analytical parameters (retention time, isotopic distribution, fragment ions, fragmentation)Aim: to get reference standards and analytical parameters to set up analytical methods (activity 2)
28/02/2016
5
WS3Activity 2: analytical methods in wastewater (IRFMN, UJI, FFULISBOA, INMLCF, EMCES, NIVA) Development, validation and standardization of analytical methods for NPS markers in wastewater Inter-laboratory standardization ? 28/02/2016
6
Slide7WS3Activity 3. analysis of NPS markers in wastewater (IRFMN, UJI, NIVA…….) Analysis for markers in wastewater from EU cities (20 EU cities are foreseen 2016 or 2017 European SCORE study ? Ask for permission to the partners ?) and music festivals (urine and wastewater in 2017 ? ) Repeated sampling in some cities (Milan, Lisbon…..)
Enantiomeric profiling studiesActivity 4: estimating NPS use in Europe (IRFMN, UJI, FFULISBOA, INMLCF, EMCES, NIVA) Estimation of NPS use, trends and pattern of consumption (from analysis of markers in wastewater and in urine)
28/02/2016
7
Expected resultsIdentification, assessment and quantification of some of the NPS most widely used in EuropeOutputs:A collection of about 100 substances (Standards, metabolites...)2 Research papers2 book chapters Meeting/Postgraduate Course (2 events)
28/02/20168