Found in all mammals Main Function Homeostasis AFFECTS MAJOR HOMEOSTATIC FUNCTIONS ENERGY INFLAMMATION SLEEP APPETITE PAIN DEVELOPMENT IMMUNE SUPPORT MEMORYLEARNING Not fully understood and their importance to homeostasis is understated ID: 1047019
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1. Endocannabinoids
2. ENDROGENOUS, LIPID-BASED NEUROTRANSMITTERFound in all mammals Main Function: HomeostasisAFFECTS MAJOR HOMEOSTATIC FUNCTIONSENERGYINFLAMMATIONSLEEPAPPETITEPAINDEVELOPMENTIMMUNE SUPPORTMEMORY/LEARNINGNot fully understood and their importance to homeostasis is understatedWhat are Endocannabinoids
3. 2-AG (2-ARACHIDONOYLGLYCEROL)ANADAMINENot “pre-made”Calcium/certain Glutamate & GABA receptors trigger enzymes for productionRetrogradeInhibitoryTWO TYPES OF ENDOCANNABINOIDS*
4. CB1 and CB2 Located on pre-synaptic neurons CB1= CNS (Hippocampus, cingulate gyrus, cerebellum, brainstem, and more)Most abundant receptor in mammalian brainPain, Appetite, MemoryTHC binds with cb1Cb2= mainly PNS (liver, spleen, b-cells, t-cells, etc.) and CNS (microglial cells, etc.)Inflammationreceptors
5. Binds to both receptorsPlays a role in:MoodMemory AppetitePain reliefBlissful state from exercise and meditationRunners highClose to THC in chemical makeupANANDAMINE
6. Much higher concentration in the brain than anandamineBinds to both receptors but especially cb1Aids in:LocomotionNeuroinflammation after brain injuriesPain sensation (blocked by cb1)Food intake (hypothalamus/forebrain during fasting)MoodLearning and memory2-AG
7. ECS=Anandamine, AG-2, CB1, CB2, and their respective enzymesNot yet fully understood, yet responsible for large portion of body homeostasis support.What we know is just the tip of the iceberg…ENDOCANNABINOID SYSTEM
8. Harvard Medical School (Harvard Publishing)https://www.health.harvard.edu/blog/the-endocannabinoid-system-essential-and-mysterious-202108112569National Library Of Medicine (An Introduction to the endogenous cannabinoid system)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789136/National Library of Medicine (Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation)https://pubmed.ncbi.nlm.nih.gov/11918654/Washington State University (Drugs and Behavior 2nd Edition)https://opentext.wsu.edu/biopsychological-effects-alcohol-drugs/chapter/chapter-13-cannabinoids/Science Direct Review (2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain)https://www.sciencedirect.com/science/article/pii/S0163782717300619Reed University Endocannabinoid Studyhttps://www.reed.edu/biology/professors/srenn/pages/teaching/web_2006/Ryan.Courtney.Website/index.html Wikipedia Endocannabinoid Systemhttps://en.wikipedia.org/wiki/Endocannabinoid_systemREFERENCES