Jackie Barlow Joseph Esdin Trish Hartzell Kalyani Maitra Miriam Martin Xia Yang amp Jim Burnette NASI Tidbit Educational context 1 sophomores biology majors in a physiology course ID: 318138
Download Presentation The PPT/PDF document "Tipsy Neurons" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Tipsy Neurons
Jackie
Barlow
Joseph
Esdin
Trish
Hartzell
Kalyani
Maitra
Miriam Martin
Xia Yang
&
Jim
BurnetteSlide2
NASI Tidbit
Educational context
1.
sophomores biology majors in a physiology course mid-semester2. students have knowledge of Basic chemistry, biology Basic molecular interactions Enzyme-substrate3. students will be expected to have read background information about neurons, synapses, neurotransmitters
KalyaniSlide3
Goals/Objectives:
After this class, students
will understand
…1. How signals are transmitted by neurons Inhibitory Excitatory2. Molecular mechanism of chemical perturbation of neuron function The story continues (next lecture) with signal transduction.KalyaniSlide4
Learning Outcomes
By the end of the lesson, students will be able to:
-Draw
the sequence of events during neuronal transmission-Compare and contrast inhibitory and excitatory synapses-Predict how receptor agonists and antagonists might interfere with neuron signal transmissionKalyaniSlide5
Assessment
Formative
Draw
the sequence of events during neuron transmissionPredict how receptor agonists and antagonists might interfere with neuron signal transmissionthe cumulative effect of multiple ligands for neuron receptorsSummativeExplain how excitation of an inhibitory pathway can lead to change of functionKalyaniSlide6
Good afternoon
TrishSlide7
Trish
Sending messages to the brain
stimulus
o
utput to brain
m
emory, coordination
b
alance, pain, pleasure Slide8
TrishSlide9
The brain is made of billions of neurons
JosephSlide10
Synapse
Presynaptic neuron
Postsynaptic neuron
Neurons form junctions called synapse and communicate by electrical signals
JosephSlide11
Synapse
Presynaptic neuron
Postsynaptic neuron
Neurotransmitter release
JosephSlide12
Neural Transmission
Neurotransmitter
Synaptic cleft
Pre
Post
JosephSlide13
Draw
the sequence of events during neuron transmission
JosephSlide14
Physiology of the Synapse
Voltage gated calcium channel
1
2
3
4
Neurotransmitter binding to ligand
gated channels (receptors)
6
5
7
7
7
Action potential
Vesicles mobilization
Neurotransmitter release
Changes in the postsynaptic neuron
Breakdown of the neurotransmitter
JosephSlide15
If neurotransmitter is
i
nhibitory
!
1
2
3
4
6
5
7
7
7
GABA release
Activity decreases in the postsynaptic neuronSlide16
If neurotransmitter is
e
xcitatory
!
1
2
3
4
6
5
7
7
7
Glutamate release
Activity increases in the postsynaptic neuron
JosephSlide17
XiaSlide18
What happens
a
fter you drink
alcohol??
?
XiaSlide19
Which image represents the effect of alcohol
on the balance between inhibition and excitation?
A
BCXiaInhibition
Excitation
Inhibition
Inhibition
Excitation
ExcitationSlide20
A
lcohol
e
xposure enhances inhibition and decreases excitation XiaGABAGlutamateSlide21
Miriam
ActivitySlide22
GABASlide23
GlutamateSlide24
How alcohol
e
nhances
inhibitory actions of GABA neurotransmissionAgonist
Jackie
(+)Slide25
How alcohol
r
educes
the excitatory actions of glutamate neurotransmissionAlcohol(-)Antagonist
JackieSlide26
Summative
JackieSlide27
Alcohol + “downers” = ???
Xanax
JackieSlide28
Thank You!!!