Michelle Hervey Pharmacology and Pharmacy - PowerPoint Presentation

Slide1

Michelle HerveyPharmacology and PharmacyVETE 430502/01/2015

Pharmacokinetics of

Fenbendazole

Suspension and Amoxicillin Suspension

Scrappy is a 6 year old, N/M, Australian Shepherd who has presented to the clinic with hematochezia for the passed couple of days. The patient is eating, and drinking normally. Upon fecal floatation

Trichuris

vulpis was for identified on the slide.

Patient History & Condition Treated

http://server.ugent.be/groups/parasitespics/wiki/3debb/Trichuris_vulpis.html

http://www.haustierratgeber.de/hunde/rassen/australian-shepherd

/

Medications Used for Treatment of Trichuris vulpis and

S

econdary Infection

Fenbendazole Suspension

Amoxacillin Suspension

http://www.msd-animal-health.co.uk/products_public/panacur_10__liquid/overview.aspx

http://store.mcguff.com/products/3855.aspx

Metabolism of Fenbendazole Suspension

This drug is only marginally absorbed after administered orally (Plumb 2011).

Amount absorbed in the gut depends on the solubility of the drug, not the dose given (Plumb 2011).

Bioavailability is increased if drug is given with food (Plumb 2011).

Fat in foods does not alter bioavailability of the drug much (Plumb 2011).

Fenbendazole is a methylcarbonate benzimidazole

antiparasitic and has a broad spectrum of activity against pathogenic parasites (Plumb 2011).

Mechanism of action is said to be the disruption of intracellular

microtubular

transport systems binding selectively and damaging

tubulin

, preventing

tubulin

polymerization, and inhibiting

microtubular

formation (Plumb 2011).

Acts at a higher concentrations to interfere with metabolic pathways within

helminths

, and inhibit metabolic enzymes (Plumb 2011).

Time dependent

antiparasitic

agent (Plumb 2011).

Fenbendazole is excreted from the intestinal tract. It is known for it’s ability to kill intestinal parasites slowly.

Elimination of

Fenbendazole

Time-dependent, bactericidal agent that inhibits cell wall synthesis (Plumb 2011).Is absorbed better orally.Relatively stable in gastric acid. Food will decrease the rate of absorption, but not the extent of oral absorption.

The drug is distributed to tissues, liver, lungs, muscle, bile,

ascitic, pleural and synovial fluids.

Metabolism of Amoxicillin Suspension

Eliminated through the kidneys through tubular secretion.Some of the drug can be eliminated in the urine.

Elimination of Amoxicillin Suspension

Fenbendazole Suspension

This drug is known as an agonist because it binds to

tubulin and damages it. This prevents

tubulin polymerization and inhibits microtubule formation (Plumb 2011).

This drug is known to be an antagonist , beta-lactam antibiotics bind to enzymes within

cytoplasmic membrane that involve cell wall synthesis (Plumb 2011). The drug inhibits or blocks cell wall synthesis of actively growing bacteria (Plumb 2011).

Agonist or Antagonist

Amoxicillin Suspension

Scrappy is given:Fenbendazole for 3 consecutive days SID for treatment of Trichuris

vulpis

. Amoxicillin for 10 days BID for secondary infection due to the intestinal parasite Trichuris

vulpis. Scrappy will return in two weeks to recheck fecal floatation to make sure he is free of intestinal parasites.

Conclusion

Plumb, Donald C.,(2011).Plumb’s Veterinary Drug Handbook 7th Edition, Pharm Vet Inc.

Romich

, Janet A.,(2010).Fundamentals of Pharmacology for Veterinary Technicians Second Edition.Delmar

References