A Noninvasive HandHeld Device for Assessing Left Ventricular EndDiastolic Pressure Based on Finger Photoplethysmography and the Valsalva Maneuver Panagis Galiatsatos MD Johns Hopkins Bayview ID: 766003
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A Noninvasive, Hand-Held Device for Assessing Left Ventricular End-Diastolic Pressure Based on Finger Photoplethysmography and the Valsalva Maneuver Panagis Galiatsatos, MDJohns Hopkins Bayview Medical CenterFebruary 2nd 2013
No Disclosures
OutlineBackground informationObjective of the studyMethodsResultsConclusions Future Direction
Background InformationKnowledge of left ventricular filling pressure useful in certain clinical settings.Non-invasive tools:Physical Exam Chest X-rayDaily weightsBloodwork (pro-BNP)
Background InformationValsalva Maneuver - Created by Antonio Maria Valsalva - Effects on the cardiovascular system
Background InformationValsalva Maneuver Phase 1: Initial blood pressure increase Phase 2: Maintaining the strain – decrease in pressure Phase 3: Release of the strain – short decrease of arterial pressure Phase 4: Distinct overshoot of pressure “Sinusoidal Response”
Background InformationValsalva Maneuver Bedside technique with sphygmomanometry Issue 1. No standardization of technique 2. Does not yield continuous measure
Background Information“Finger photoplethysmography during the Valsalva maneuver reflects left ventricular filling pressure” Silber HA et al. Am J Physiol Heart Circ Physiol 2012Photoplethysmograph (PPG)Pulse Amplitude Ratio (PAR)
ObjectiveValidate a new hand-held, battery-powered device that inputs finger PPG and expiratory pressure signals during the Valsalva maneuver, guides subject performance and calculates PAR automatically.
Mouthpiece / pressure transducer Photoplethysmography (PPG) probeUser-friendly display A A B B C C
MethodsPatients who were scheduled to undergo a cardiac catheterization including the measurement of LVEDP. Expiratory pressure during Valsalva was measured by having the subject place a tube in their mouth that was connected to a pressure transducer input into the device.
MethodsThe subject was coached to keep the expiratory effort at about 20 mmHg during a 10-second Valsalva maneuver. The output measure of the device is the ratio of the amplitude of the PPG waveform near the end of Valsalva to the amplitude at baseline
Methods
Results
Characteristics All Patients (N=14) + SD Age 53 + 8.5 Female 7 (50%) BMI (kg/m 2 ) 33.1 + 7.6 Co-Morbidities Hypertension (n) Hemodialysis (n) Diabetes mellitus (n) Coronary Artery Disease (n) 7 (50%) 2 (14%) 4 (29%) 8 (57%) Medications Calcium channel blockers (n) Beta blockers (n) Thiazide diuretics (n) ACE-I / ARB (n) Loop diuretics (n) 1 (7%) 9 (64%) 1 (7%) 9 (64%) 1 (7%)
PAR > 0.72 was 78% sensitive and 100% specific in identifying LVEDP > 15 mmHg.
ConclusionsThis study represents initial testing of a hand-held, battery-powered device using finger PPG during the Valsalva maneuver for assessing left ventricular filling pressure noninvasively. The output measure of the device, Pulse Amplitude Ratio (PAR), correlated well with LVEDP obtained invasively by cardiac catheterization.
ConclusionsPAR > 0.72 was 78% sensitive and 100% specific in identifying LVEDP > 15 mmHg, a clinically meaningful cutoff value in heart failure.Further testing is warranted to explore the clinical utility of this device in heart failure management and other settings.
Future DirectionsUse of the device to assess adequate fluid removal from in-patient diuresis in heart failure patients. PAR in the use of fluid removal in hemodialysis.
AcknowledgementsHarry Silber, MD, PhDPrincipal InvestigatorJennifer Monti , MD, MPHInterventional CardiologistsDavid Bush, MDJeffrey C. Trost, MDPeter Johnston, MDColleen Christmas, MD
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