209 ObesityPrevent rather than cure Ashfaq Ul Hassan Samia Rasheed Amin Tabish Rashid RatherSajad Hamid Zahida RasoolSKIMS Medical College SMHS Hospital SKIMS IUST ID: 954526
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JIMSA July-September 2012 Vol. 25 No. 3 209 Obesity-Prevent rather than cure: *Ashfaq Ul Hassan,** Samia Rasheed, ***Amin Tabish, *Rashid Rather,**Sajad Hamid, **** Zahida Rasool*SKIMS Medical College, SMHS Hospital, ***SKIMS, ***, IUST Kashmir, India 210 JIMSA July-September 2012 Vol. 25 No. 3 210 -Differences in leptin sensitivity and/or leptin production have beensuggested to play a role in the pathogenesis of obesity. The majorityConsistently, obesity is associated with Histological changes of the type:-Increase in numbers of adipocytes,-Increase in size of adipocytes,-Infiltration of adipose depots by mononuclear cells-Relative rarefaction of blood vessels,-Relative rarefaction of neural structures. carry the vascular supply.-The obese peoples fat cells showed stress on the endoplasmic-Obese individuals have a relatively large amount of hypertrophic-The specific activity of the lipogenic marker enzyme G3PDH was-Omental adipocytes from obese subjects also had lower basalFAT CELL NUMBERS ARE SET FOR LIFEtime. Even extreme weight-loss strategies, such as bariatric surgery, do notthrough late childhood and early puberty, after which it is pretty much set.Fat cell number increases more rapidly in obese children than in lean children.QUANTITY VERSUS SIZE OF FAT CELLSto have a similar fat percentage. For example if someone had 500 millionfat cells and a second person only had 300 million fat cells, these two peopleFAT CELLS ONCE GAINED ARE NEVERLOST.number which remains const
ant. A fat cell is 95% fat. If it dies, it leavesTHE NUMBER OF FAT CELLS ISGENETICALLY PREDETERMINEDobese. Accumulation of various characters such as sedentary life style,The longer the course of obesity, the more difficult it is to have it treated.Two of the Healthy People 2010 national health objectives are:-to reduce the prevalence of overweight and obesity among adults-to reduce the prevalence of obesity among children and adolescentsto help people understand the severity of obesity, the efforts beingRESULTGiven the serious nature of chronic diseases and conditions associated withimportant. The fact that both medical and surgical treatments for curingprevention at an early stage with concurrent reduction in the occurrence ofMaffei M, Halaas J, Ravussin E, Pratley R E, Lee G H, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan1995) Nat Med 1:11551161, pmid:7584987.Considine R V, Sinha M K, Heiman M L, Kriauciunas A, Stephens T W, Nyce M R, Ohannesian J P, (1996) N Eng J Med 334:324325Considine R V, Sinha M K, Heiman M L, Kriauciunas A, Stephens T W, Nyce M R, Ohannesian J P, (1996) N Eng J Med 334:324325,Considine R V, Considine E L, Williams C J, Nyce M R, Magosin S A, Bauer T L, Rosato E L, ColbergLonnqvist F, Arner P, Nordfors L, Schalling M (1995) Nat Med 9:950953.1994 Fatty acids, hyperinsulinemia and insulin resistance: which comes first? Currentand Improving Health and Objectives for Improving Health. 2 vols. Washington, DC: U.S. GovernmentPrinting Office, November 2000