mitomycin C balloon dilatation in intractable esophageal stricture Eun Young Chang Young Ju Hong Jung Tak Oh Seok Joo Han Department of Pediatric Surgery Severance Childrens Hospital Department of Surgery ID: 774918
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Slide1
The clinical experience of mitomycin C balloon dilatation in intractable esophageal stricture
Eun Young Chang, Young Ju Hong, Jung-Tak Oh, Seok Joo Han
Department of Pediatric Surgery, Severance Children’s Hospital, Department of Surgery,
Yonsei
University College of Medicine, Seoul, Korea
Slide2Purpose
Esophageal strictures refractory to conservative treatment represent a major problem in
children.
Recently, the application of
mitomycin
C to the lesion of strictures has been introduced.
We investigated our clinical experience with this procedure in refractory esophageal stricture.
Slide3Methods
From September 2011 to September
2013
16 patients:
15 esophageal
stricture after the surgery of esophageal
atresia
1 corrosive
esophageal injury due to lithium battery ingestion after
esophagectomy
Mitomycin
C balloon dilatation
Drug
eluting
microporous
PTFE balloon catheter after pre-balloon
dilatation
under the general anesthesia by intervention radiologist
Slide4Methods
Pre-
Pre-balloon
Mitomycin
C
After-
Slide5Results
CharacteristicsN=16Sex (M/F)7/9Age at Mitomycin C dilatation9.3 months (2.9-41.9)Body weight at Mitomycin C dilatation6.1 kg (3.2-12.6)Diameter of stricture 3.0 mm (1.5-8.0)Length of stricture 5.3 mm (1.1-20.0)Numbers of esophageal dilatation before procedure2 (0-8)Numbers of esophageal dilatation after procedure0 (0-4)
* All variables are expressed by median values with range.
Slide6Results
Numbers of esophageal dilatation pre-/post- mitomycin
Slide7Results
After
Mitomycin
C esophageal dilatation,
5 patients
were needed further dilatation.
1 : severe
small diameter of stricture
(1.55mm
)
(n: 4
4)
1: lithium
battery ingestion,
(n:1
4)
1: clinically severe
stenosis
: 01
1: decreased, (n:81)
1: decreased, (n:72)
11 patients: never needed further dilatation
Slide8Results
Complications
one
patient
a
partial tearing of esophagus during the
procedure
followed
pancytopenia
, thrombocytopenia
r
ecovered through
conservative
treatment
Follow-up duration: 8.3 months(r: 0.5-22.3)
All patients were not complain
dysphagia
Slide9Conclusion
Although this study is retrospective, small sample sized, not randomized, and limited follow-up,
Mitomycin
C balloon dilatation in refractory esophageal stricture is safe and feasible.
For
further indication, prospective, long-term assessment of outcome is needed.