PPT-Project: HIV RT inhibition

PREVIOUS PRESENTATION HIV BIOLOGY and PROJECT BASICS THIS PRESENTATION HIV THERAPY ITs DRAWBACKS and OBJECTIVES OF THE PROJECT TITAS MALLICK TITAS MALLICK UNIVERSITY OF CALCUTTA INTRODUCTION. Despite this signi64257cant progress the number of children becoming newly infected with HIV remains unacceptably high About 240 000 210 000280 000 children became infected with HIV in 2013 The risk of a mother living with HIV passing the virus to h Week 2:. Organophosphate . Insecticides. a. Acute toxicity. Categories of Effects. Muscarinic. Mimic action of muscarine. Peripheral nervous system only. Smooth muscle, heart, exocrine glands. Bronchoconstriction, salivation, lacrimation, perspiration. (Inorganic phosphate & Sodium fluoride) on the rate of an enzyme catalyzed reaction. Type of Inhibitors . There exist a number of molecular species which, in the presence of an . enzyme and its substrate. Inhibition is a term used to describe the inability of a product being formed due to the presence of another substance (the inhibitor). Enzyme inhibition . can be competitive or noncompetitive. Competitive inhibition is caused when an inhibitor “competes” with the substrate in binding with the enzyme. Pratt & . Cornely. . Ch. 7. Other Factors. Other factors affect enzyme activity. Temperature. pH . pH Optimum. Determined by structural stability. Compartmentalization. Determined by active site residues. Week 2:. Organophosphate . Insecticides. a. Acute toxicity. History. World War II nerve gases. Britain. Germany. Gerhard Schrader. TEPP as first commercial OP insecticide. Post-WWII transfer of IG Farben chemicals to US. Lecture #42. 1. Outline. Allometry. Microdosing. Predicting Clearance. Absorption, Distribution and . Metabolism. Whole Body Physiological Models. Predicting Pharmacodynamics. Virtual Patient Populations. 1. Dr. Nikhat Siddiqi. The most responsive regulation of amino acid . synthesis takes . place through feedback inhibition of the first . reaction in . a sequence by the end product of the pathway.. This first reaction is usually irreversible and . (e). Describe the action of competitive inhibitors. Describe the action of non-competitive inhibitors. Describe the action of feedback inhibition. Describe and identify the impact of each of the above on the rate of reaction and through a graph of results. . Christian Stricker. Associate Professor for Systems Physiology. ANUMS/JCSMR - ANU. Christian.Stricker@anu.edu.au. . http:/. /stricker.jcsmr.anu.edu.au/NeuronalNetworks.pptx. THE AUSTRALIAN NATIONAL UNIVERSITY. Katie Kelly Brennan, DVM. Johns Hopkins University School of Medicine . Department of Molecular and Comparative Pathobiology. Objectives. Discuss HIV-associated cardiac dysfunction and describe our simian immunodeficiency virus (SIV)/macaque model. HIV1 and slower to progress to AIDS.. Most cases are due to type1.. Modes of transmission. 1-sexual.. 2- perinatal.. 3-parenteral(occupational and intravenous drug injection).. 4- blood transfusion.. Inhibition-. The decrease in enzyme activity/loss of activity. exert effect by decreasing . affinity of the enzyme for the substrate. decreasing the amount of active enzyme available for catalysis. by a combination of these effects. AMVAC Chemical Corporation. FMC Corporation. Gowan. Company. September 15-18, 2020. Outline of Presentation. Introduction to Testing Program (Rick Reiss) – 15 minutes. Experimental Procedures and Results (Jan Chambers) – 20 minutes.