PPT-Therapeutic monoclonal antibodies & blood transfusion

Essential information for hospital transfusion laboratories transfusion practitioners amp haematology clinical teams Background Targeted therapeutic monoclonal antibodies are used to treat patients with myeloma and other haematological malignancies. presented by . Dr Azza Serry. Blood transfusion. . Blood . is a precious as the only source is the human being , so handling of the blood should be conducted with the deserved dignity and administered in its proper indication . . mAbs. ): . Three Decades Of Innovation And Progress. History Of Discovery. . Discovery . of tetanus and diphtheria . antitoxins. 2. Paul Ehrlich proposes “Side-Chain Theory” for antibody & antigen (lock & key) interaction. NIS Uralsk. Medical use of Antibodies. Monoclonal antibodies (. mAbs. ) are pure, single antibody types that are industrially . produced.. Clones . of one type of immune . cell.Typical. . production:. Monoclonal Antibody Production. Method. Monoclonal Antibody Production technology was developed in 1975. Since its development it has been very important in the modern medical science with the diagnosis, therapy, research and even basic science today. It is still largely dependent upon animal testing however. Because it requires immunization of mice in order for them to create the antibodies to be grown. . Presented by . Jacie. . Mundahl. , MLS (ASCP). cm. 1. Objectives. Upon . completion of this presentation the participant will be able to recognize the effects of daratumumab in immunohematology patient testing and manage those patients in future visits. . Daradka. University Of Jordan. School Of Medicine. General . S. urgery Department . A Transfusion Dilemma. A 72 year old woman presents to ER with a nosebleed. This is her second visit in 24 hours with the same complaint. Her nose is packed and the bleeding stops.. David A. Nace, MD, MPH, CMD. Associate Professor of Medicine. Clinical Chief. Division of Geriatric Medicine. University of Pittsburgh. December 17, 2020. Speaker Disclosures. Dr Nace has no relevant financial disclosures.. Dr Bijan Keikhaei. Full Professor of Pediatric . Hematology and Oncology. Research Center for Thalassemia and Hemoglobinopathy, Health Institute, Ahvaz Jundishapur University of Medical Sciences. Introduction. . antibodies. Polyclonal. . antibodies. PAbs. . are secreted by different B cell lineages . They are a . collection of immunoglobulin . molecules that react against a specific antigen, each . identifying a different . Therapeutic monoclonal antibodies (mAbs) are biologics that have been used for decades to treat various conditions, including rheumatoid arthritis, asthma, as well as various cancer s and infect Medical use of Antibodies. Monoclonal antibodies (. mAbs. ) are pure, single antibody types that are industrially . produced.. Clones . of one type of immune . cell.Typical. . production:. Monoclonal antibodies = . Transfusion. Describe the ABO and Rhesus blood group systems . . Recognize agglutinins in the plasma. Describe grouping, cross-matching & typing with anti-sera . List precautions taken in preparing blood for transfusion and storage of blood . Learning outcomes. Student should be able to understand the following:. Antibody structure and the formation of an antigen-antibody complex. The use of monoclonal antibodies in enabling the targeting of specific substances and cells.. Understanding . Compatibility . for Transfusion Safety. . Donna Berta RN, BScN. Clinical Project Coordinator – Nursing. Ontario Regional Blood Coordinating Network (ORBCoN). March 27, 2024. Speaker Disclosure.