Wang Kloth and Badura 2014 Neuron Anatomy Highly folded surface area 500 cm 2 compared to 2300 cm 2 of cerebral cortex 3layered Granular Purkinje Molecular Voogd Glickstein 1998 Trends Neurosci 21370375 ID: 1042543
Download Presentation The PPT/PDF document "What does the cerebellum do during devel..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
1. What does the cerebellum do during development and adult life?
2.
3. Wang, Kloth, and Badura (2014) Neuron
4. AnatomyHighly folded, surface area 500 cm2 (compared to 2300 cm2 of cerebral cortex)3-layered: Granular, Purkinje, Molecular Voogd, Glickstein (1998) Trends Neurosci, 21:370-375slice by Thomas Deerinck
5.
6.
7. CS (light flash) + US (airpuff to cornea)
8.
9. Najafi et al. (2014) Cell ReportsNajafi et al. (2014) eLife
10. Giovannucci, Pneumatikakis, Paninski, Wang
11.
12.
13.
14. ASD gene co-expressionRisk ratiosWang, Kloth, and Badura (2014) Neuron
15. Autism DefinedAlonenessSameness
16. Wang, Kloth, and Badura (2014)
17. Wang, Kloth, and Badura (2014)
18. Cerebellum, developmental sensitive periods, and autismThe cerebellum is a multisensory processor.Cerebellar dysfunction in early life can lead to autism spectrum disorder.Autism risk factors may lead to early-life difficulties in sensory processing. Experience is a guide for social brain development, so these difficulties may lead to autism.
19.
20. Alexander Kloth
21.
22.
23. Pilot study – Do DREADDs work in the cerebellum?RESEARCH PLANInject different AAV DREADDs into the eyeblink zone and look for expression pattern and behavioral changesLigand-induced neuronal silencing:Designer receptor exclusively activated by designer drugs DREADDs
24. Social behavior – 3 chamber task
25.
26.
27. Broad Autism PhenotypePresent in 30% of parents of autistic children and 3% of parents of non-autistic childrenQuantified by the BAPQ, three subscores
28. BAP prevalence:14-23% in parents of ASD children5-9% in comparison parentsSasson et al. 2013 Autism Res. 6:134-143Hurley et al. 2007 J Autism Dev Disord 37:1679-1690
29. GWAS on BAPQ scores~3000 parents from the Simons Simplex Collection have BAPQ scoresThree subscores: aloof, pragmatic, and rigid, and an overall scoreDownsides: database strongly selects for de novo autism
30.
31. SW
32.
33. Evidence for complex inheritance of mental traits Twin concordance ` Heritability (h2) Monozygotic DizygoticHeight 0.85 Bipolar 0.7-0.8 62% 8%Numerical ability 0.76 Autism 0.7 60-92% 0-30%Verbal ability 0.63Depression 0.4 46% 20% Substance abuse 0.34 26% 16% Acne ~0 14% 14%
34. Campbell and Wang (2012) PLoS ONE
35. Intellectual InterestCampbell & Wang (2012): technical majors are 3 times more likely to have a sibling with autism than humanities majorsSource: Campbell, B. C. & Wang, S. S.-H. Familial linkage between neuropsychiatric disorders and intellectual interests. PLoS One 7, e30405 (2012).
36.
37. The number of synapses peaks in early childhoodHuttenlocher PR (1990) Neuropsychologia 28:517-527Chugani HT (1998) Preventive Medicine 27:184-188Welcome To Your Child’s Brain
38.