Practicum in Health Science Key Definitions Reconstitute to change into liquid form by adding water or other fluid to a powder Diluent the liquid added to a powder during reconstitution ID: 265263
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Slide1
Reconstitution
Practicum in Health ScienceSlide2
Key Definitions
Reconstitute
: to change into liquid form by adding water or other fluid to a powder.
Diluent
: the liquid added to a powder during reconstitution.Slide3
Reconstitution Basics
Solids – powders or crystals
Liquids – water or sterile solutions
Necessary for medications which are unstable
Done according to:
Physical properties of drug
Route of administration
Concentration may varySlide4
Reconstitution Solids
and Diluents
Solids
Single or
multidose
containers
Diluents
Oral medications – distilled water only
Injectable medications – sterile solutions that vary with the drugMix-O-VialDiluent packaged with drug (ex. Immunizations)Slide5
Reconstitution at
Different Strengths
Single-strength, single-dose
Use
diluent
amount on label
Multidose
Use label to adjust the
diluent amountChoose amount closest to achieving physician’s ordered strengthSlide6
Reconstitution for Different Administration Routes
Intramuscular and intravenous medications can differ
Intramuscular drugs may require a variety of diluents – especially if injection is long-acting
Some medications can only be administered by one route
Some medications with interchangeable routes require different amounts of diluentsSlide7
Equipment needed for Reconstitution
Graduated cylinder
or similar product
Reconstitube
® - a modified graduated cylinder with two tubes attached. The upper tube connects the cylinder to a supply of water or other liquid, and the lower tube, which is open ended, enters the medication bottle. Slide8
Reconstitution Procedure
Tap the container to loosen the solid in the container
Read all directions on the medication label
Use the manufacturer-designated
diluent
in the amount needed to achieve the physician-ordered medication concentration.
**TIP ** Only add one-third portion of the
diluent
to the medication bottle at first, allowing the powder to dissolve gradually into the diluent. If you add all liquid at once, medication powder will likely stick to the bottom of the medication bottle and resist dilution. Following reconstitution, container is ready for the attachment of the prescription label. Don’t forget to affix any appropriate auxiliary labels. Slide9
Original Product Package Label Sample: for reconstitution to liquidSlide10
Check for
Understanding
1.
If
a Reconstitube® is unavailable, what other compounding equipment would be appropriate to use for measuring the diluent?
a. Mortar
& pestle
c. Graduated cylinder
b. Amber bottle d. Oral syringeReferring to the previous sample label, once the diluent has been added to the powder medication, what is the final concentration in milligrams per milliliter? a. 25 mg/ml c. 100 mg/ml
b. 50 mg/ml d. 250 mg/mlSlide11
Check for understanding
Based on the concentration that was determined in question 2, how much of this medication would be needed for a 125 mg dose?
a. 2 ml c. 5 ml
b. 3 ml d. 10 ml
If the physician orders “Augmentin 125 mg po
qid
,” how much of this solution would be needed for a 24-hour period?
a. 5 ml c. 15 ml
b. 10 ml d. 20 mlSlide12
Sources
McCartney, L. & Sparks, J. Pharmacy Labs for Technicians: Building Skills in Pharmacy Practice.
EMC Publishing, LLC. 2010.
University of Florida College of Pharmacy:
www.cop.ufl.edu/wp-content/uploads/dept/ce/pharm_tech/slidehandouts/dosagecalc.pdf