Update J Paul Martin MD 4 5 NC State Ctr for Hlth Stats WNC Higher Than the National Ave Hypertension Diabetes Elevated Cholesterol Obesity Hypertension WNC Higher Than the National Ave ID: 617664
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Slide1
2017Hypertension
Update
J. Paul Martin, MDSlide2Slide3Slide4
4Slide5
5Slide6Slide7
NC State
Ctr for Hlth Stats
WNC Higher Than the National Ave.
Hypertension
Diabetes
Elevated Cholesterol
ObesitySlide8
Hypertension
WNC Higher Than the National Ave.
1 in 3 Adults in US have HTNOur local HRA’s found >50% HTN in several employee groups
55 YO with normal BP has 90% chance of developing HTN during lifetime
<50% of those treated reach goalSlide9
Joint National Committee
US Dept. of Health and Human Services
National Institutes of Health
National Heart, Lung, and Blood Institute
JNC 1 – 1976 normal diastolic <90
JNC 3 – 1984 normal systolic < 140
isolated systolic
htn
>160
JNC 7 – 2003 normal < 120/80
JNC 8 – December 2013 normal <120/80
On Prevention, Detection, Evaluation
And Treatment of High Blood Pressure (JNCOPDEATOHBP8)Slide10
BP Classification (JNC-8)
Normal < 120/80
Pre-hypertensive – 120-139/80-89Hypertension >140/90Stage 1: 140-159/90-99Stage 2: >
160/100Slide11
Other Advisory Groups
American Diabetes Association
American Society of Hypertension /International Society of Hypertension
European Society of Hypertension/ European Society of CardiologySlide12
Proper BP MeasurementSlide13
Proper BP Measurement
Locate brachial artery on inner upper arm
Place the middle of the cuff over the brachial artery. The lower edge of the cuff should be 1” above the antecubital space.Tell the patient not to talkDetermine the maximum inflation point by palpating the radial artery and rapidly inflating cuff (palpated systolic). To that add 30 mm HgSlide14
Proper BP Measurement
Deflate cuff rapidly and wait 15 – 30 seconds before re-inflating.
Apply the stethoscope bell lightly over the palpated brachial arteryInflate cuff rapidly to palpable systolic pressure + 30 mm Hg
Release the air so pressure drops 3 mm Hg/secSlide15
Proper BP Measurement
Listen for at least two consecutive beats (
Korotkoff sounds Phase 1) i.e. the systolic BP Listen for a muffling of the sounds in children or the absence of the sounds in adults (Korotkoff sounds Phase 4 or 5). This is the diastolic BP
Continue listening for an additional deflation of 10 – 20 mm Hg to confirm findings.
Don’t repeat for 1-2 minutes to allow trapped blood to be released from veins.Slide16
Proper BP Measurement
Total Time:
5 minutes sitting30 seconds to apply & palpate systolic BP30 seconds wait45 seconds to re -inflate & slowly deflate
Total Time approx. 7 minutesSlide17
Treatment of high blood pressure
Decrease risk of stroke 35-40%
Decrease risk of heart attack 20 – 25%Decrease risk of CHF > 50%
WHY?Slide18
Treatment of high blood pressure
In stage 1 HTN and additional CVD risk factors, achieving a sustained 12 mmHg reduction in SBP over 10 years will prevent 1 death for every 11 patients treated.Slide19
Treatment of high blood pressure
>
60 yrs of age systolic BP is major predictor of coronary artery disease50-59 systolic and diastolic BP are equal predictors of coronary artery disease< 50 Y/O diastolic BP is major predictor of coronary artery diseaseSlide20
Treatment of high blood pressure
What is the target?
Slide21
BP Treatment Recommendations
Joint National Committee
Normal < 120/80Pre-hypertensive – 120-139/80-89NOT a disease category
It IS a risk categorySlide22
Treatment of high blood pressure
What is the target?
Slide23
Treatment of high blood pressure
What is the target?
< 140/90 Slide24
Treatment of high blood pressure
What is the target?
< 140/90 …..with some caveats JNC-8
Slide25
Definitions
CVD – Cardiovascular Disease PVD – Peripheral Vascular Disease
CBVD –
Cerebrovascular
Disease
CAD – Coronary Artery Disease RVD – Renal Vascular Di
sease
Slide26
Definitions
Uncontrolled BP (>140/90 mmHg) despite:
the use of 3
antihypertensives
including a diuretic =
Resistant Hypertension
the use of 5
antihypertensives
including long-acting thiazide and mineralocorticoid receptor antagonist =
Refractory Hypertension
Slide27
Joint National Committee
JNC 1 – 1976
Thiazides
for DBP
>
105
JNC 3 – 1984 ß-Blockers added as initial therapy option
JNC 4 – 1988 ACEI and CBB added as initial therapy options (despite no RCT’s)
JNC 5 – 1993 Evidence-based:
Thiazides
and
ß-Blockers preferred initial agents
JNC 6 – 1997 Any of the seven classes could
be appropriate initial option
Slide28
JNC 7 - 2003
Thiazides
as initial therapy for “most”
ACEI, ARBs, CCBs,
ß-Bs appropriate first line in those with compelling indication
Stage 2 hypertensives
(
> 160/100) should be started on two medications (one a thiazide)
BP target for high-risk CVD
<
130/80
Slide29
JNC 7 - 2003
Thiazides
as initial therapy for “most”
ACEI, ARBs, CCBs,
ß-Bs appropriate first line in those with compelling indication
Stage 2 hypertensives
(
> 160/100) should be started on two medications (one a thiazide)
BP target for high-risk CVD
<
130/80
Slide30
JNC 8 - 2013
The JNC-8 guidelines provide practice guidance for patients aged ≥18 years across a number of pre-specified subgroups, such as diabetes, chronic kidney disease, CVD, older adults, sex, racial and ethnic groups, and smokers.
Slide31
What constitutes good care?How important is diet, exercise, weight control?
What medications are available?Which ones actually work?How low should you go?Slide32
Diet, Exercise, & Weight Management Slide33Slide34
Diet, Exercise, & Weight Management Slide35
Treatment of high blood pressure
Diet 8-14 mmHg
Exercise 4-9 mmHgWeight control 5-20 mmHg/10KgDietary
NaCl
2-8 mmHg
Magnesium 2-3 mmHg
Approx SBP reductionSlide36
Diet, Exercise, Weight ManagementSlide37
Primary Prevention of HTN
Calcium supplementation, fish oil,
reduction of caffeine: Prudent for general health
Minimal effect on lowering BP or preventing HTNSlide38
Primary Prevention of HTN
Drugs which may induce hypertension:
Adrenal SteroidsOral ContraceptivesNSAIDSStimulants
SympathomimeticsSlide39
Primary Prevention of HTN
While caffeine can acutely increase BP, studies have not shown a linear relationship between caffeine intake and incident
morbidity To judge effect of caffeine on your BP, measure BP 30-60 minutes after intake.Slide40
What constitutes good care?
How important is diet, exercise, weight control?What medications are available?Which ones actually work?How low should you go?Slide41
MedicationsSlide42
MedicationsSlide43
Medications
Thiazides
Beta BlockersACEI / ARBsCalcium Channel BlockersMineralocorticoid Receptor Antagonists
Alpha 2 Adrenergic Agonists
Alpha 1 Adrenergic Receptor Blockers
Direct VasodilatorsSlide44
Medications -
Thiazides
JNC-7 - Thiazide Diuretics should be initial hydrochlorothiazide (hctz),
chlorthalidone
,
indapamide
Most patients will require more
than one medication to reach
their BP goalSlide45
Medications -
Thiazides
Hydrochlorothiazide doses > 25mg/d are seldom justifiable based on published evidence of outcomes & adverse effectsLong acting thiazides such as chlorthalidone
and
indapamide
are indicated in resistant or refractory hypertensionSlide46
Medications -
ThiazidesSlide47
Medications -
Thiazides
Thiazides may induce glucose intolerance Keep Potassium > 4.0 mEq/L (consider
KCl
,
ACEI, ARB, triamterene
,
amiloride
, spironolactone)
Prior Stroke –
Thiazide
& ACEI
In HYVET (age >80)
indapamide
+ ACEI
21% decrease in all cause mortality
30% reduction in CVA
64% reduction in CHFSlide48
Medications -
Thiazides
Reduce excretion of:Calcium (fewer Ca++
kidney stones)
Uric Acid ( increasing risk of gout)
Lithium (increasing risk of toxicity)
Increase excretion of
:
Potassium
MagnesiumSlide49
Medications -
Thiazides
NaCl restriction enhances response to thiazides
High Dietary salt intake offsets responseSlide50
Medications – Loop Diuretics
Thiazide diuretics typically considered ineffective when GFR < 30-40 ml/min (except
metolazone-Zaroxyln)Substitute furosemide or torsemide
(loop diuretics)Slide51
Medications – Loop DiureticsSlide52
Beta Blockers have fallen from grace as single agents in HTN except in patients with CAD (?)
Atenolol should be given BIDAvoid Beta Blockers in
Prinzmetal AnginaJAMA Oct 3, 2012 45,000 patient observation – no lower risk of composite CV events with Beta Blockers even in patients s/p MI (distant) – REACH study
Medications – Beta BlockersSlide53
Medications – Beta Blockers
Older beta-blockers (propranolol, atenolol, metoprolol) worsen insulin resistance
The vasodilating beta-blockers (carvedilol, labetolol,
nebivolol
) don’t have this effect
Slide54
Medications – Beta Blockers
Cochrane Database
Syst Rev 2007 RCTs assessing the effectiveness of beta blockers
compared to placebo, no therapy or other drug classes,
as
monotherapy
or first-line therapy for HTN, on
morbidity and mortality endpoints
13 RCTs; 91,561 subjects
Available evidence does not support the use of beta blockers as first-line agents in HTN treatmentSlide55
Medications – Beta Blockers
Bisoprolol
(Zebeta), carvedilol (
Coreg
) and sustained-release
metoprolol
(
ToprolXL
) are specifically indicated as adjuncts to standard ACE inhibitor and diuretic therapy in congestive heart failure.
Slide56
Medications – Beta Blockers
Rebound Hypertension
Short –acting
β
-blockers such as:
Propranolol
Atenolol
Metroprolol
Rapid disappearance of
β-
blockade
-Loss of protection against ischemia
-Loss of antihypertensive effect
-Subsequent enhanced
β-
receptor mediated responsesSlide57
Medications – Beta Blockers
Rebound Hypertension
Short –acting
β
-blockers such as:
Propranolol
Atenolol
Metroprolol
Rapid disappearance of
β-
blockade
-Loss of protection against ischemia
-Loss of antihypertensive effect
-Subsequent enhanced
β-
receptor mediated responses
Partial compliance with
β
-blocker treatment is
Associated with increased risk of sudden death Slide58
Medications ACEI/ARBs
ACE Inhibitors (
benazepril, enalapril, lisinopril)
ARB (losartan,
irbesartan
, candesartan, valsartan)
Cough,
angioedema
,
hyperkalemia
, ARF
ONTARGET – no benefit combining
- led to increased renal impairmentSlide59
Medications ACEI/ARBs
ACE Inhibitors, ARBs and Aldosterone Inhibitors all lessen insulin resistanceSlide60
African Americans & ACEI/ARBs
Htn
is commonly of low renin typeSensitivity of blood pressure to salt intake is often increased
The
ability to excrete ingested salt is impaired (60–70
%)
This leads to an overall expansion of intravascular volume.
Obesity
is especially prevalent in black women and is associated with an increase in total body sodium content
.
Intake of dietary potassium, in the form of fruit and vegetables, is generally lower in blacks than in whites.
Black
patients may also have relatively higher concentrations of intracellular
calcium
Heart. 2005 Aug; 91(8): 1105–1109 “Management of Hypertension in Ethnic Minorities”Slide61
Medications ACEI/ARBsSlide62
Medications ACEI/ARBsSlide63
Medications ACEI/ARBs
Should be use in the population
> 18 yrs with CKD or DM to improve kidney outcomesThis is regardless of race
Do
NOT
use an ACEI and ARB togetherSlide64
Medications ACEI/ARBs
42 YO Asian female with HTN and type 2 DM has baseline serum Cr of 1.7 mg/
dL. Her BP is 147/92. She is started on lisinopril. Two weeks later her BP is 128/78. Her serum Cr = 2.1.
A repeat serum Cr 1 week later is unchanged.
Which is the most appropriate course of action? Slide65
Medications ACEI/ARBs
A.
Continue the lisinopril at the same dosage
B. Reduce the
lisinopril
dosage
C. Discontinue the
lisinopril
D. Switch to an ARB
E. Evaluate the patient for bilateral renal stenosisSlide66
Medications - CCBs
Dihydropyridines
(amlodipine, nifedipine
)
Non-
dihydropyridines
(
verapamil
,
diltiazem
)Slide67
Medications - CCBsSlide68
JNC 7 - 2003
Thiazides
as initial therapy for “most”
ACEI, ARBs, CCBs,
ß-Bs
appropriate first line in those with compelling indication
Stage 2 hypertensives (>160/100) should be started on two medications (one a thiazide)
BP target for high-risk CVD
<
130/80
Slide69
Medications for Compelling Indications
Htn & Stable Angina – beta blocker (?CCB)Htn & CHF – beta blocker & ACEI
Chronic Kidney Disease – ACEI or ARB
Diabetes – ACEI or ARB
Prior Stroke –
Thiazide
& ACEI
Slide70
JNC 8 - 2013
Thiazides ACEI, ARBs, CCBs,
appropriate first line based on physician/patient preference.Thiazides and calcium channel blockers are preferred for black patients because of improved cardiovascular and cerebrovascular outcomes, and more effective blood pressure reduction in this population
.
Slide71
JNC 8 - 2013
If after 30 days BP has not reached goal of <140/90 either the dose should be increased or a second drug added from initial list Slide72
JNC 8 - 2013
54 YO African American female presents for routine evaluation with BP 164/106
. Which antihypertensive meds would you initially consider?
Chlorthalidone
& Amlodipine
Lisinopril & Atenolol
Losartan (
Cozaar
) & Atenolol
Prazosin & Atenolol
Clonidine or
MinoxidilSlide73
Medications
Thiazides
Beta Blockers
ACEI / ARBs
Calcium Channel Blockers
Mineralocorticoid Receptor Antagonists
Alpha 2 Adrenergic Agonists
Alpha 1 Adrenergic Receptor Blockers
Direct VasodilatorsSlide74
Mineralocorticoid Receptor Antagonists
In resistant or refractory HTN consider spironolactone
In HTN associated with Obstructive Sleep Apnea consider spironolactone (
Aldactone
)
Eplerenone
(
Inspra
) is 6X as expensive – reserve for those requiring >50mg
spironolactone
with side effects
Slide75
Medications - SpironolactoneSlide76
Alpha-2 Adrenergic Agonists
Centrally-acting Clonidine (
Catapres
)
Guanfacine
(
Tenex
)
Methyldopa (
Aldomet
)
Dexmedetomidine
(
Precedex
),
Tizanidine
(
Zanaflex
)Slide77
Centrally-acting Alpha-2 Adrenergic Agonists
Slide78
Centrally-acting Alpha-2 Adrenergic Agonists
Slow heart rate / lower BPPotential for rebound HTN (esp. >1.2mg clonidine long term >2 months)Should be avoided in CHF – negative chronotropic and inotropic effects. Slide79
Centrally-acting Alpha-2 Adrenergic Agonists
Off Label
Chronic Pain (neurogenic/hypersensitivity)ADD/ADHDNarcotic WithdrawalBehavioral Issues Slide80
Alpha-1 Adrenergic Receptor Blockers
Peripheral
Doxazosin (Cardura
)
Prazosin
(
Minipress
)
Terazosin
(
Hytrin
)
Slide81
Peripherally-acting Alpha-1
Adrenergic Blockers
Slide82
Potpourri of Medication Updates
Direct Vasodilators
Hydralazine (
Apresoline
)
Minoxidil
Slide83
Medications
Thiazides
Beta Blockers
ACEI / ARBs
Calcium Channel Blockers
Mineralocorticoid Receptor Antagonists
Alpha 2 Adrenergic Agonists
Alpha 1 Adrenergic Receptor Blockers
Direct VasodilatorsSlide84
Treatment of high blood pressure
What is the target?
< 140/90 …..with some caveats
Slide85
JNC-8 Target for Age >60
<150/90
<140/90 if tolerated with no adverse effects and for those with high CV risk
Endorsed by ACP & AAFP 2017Slide86
JNC-8 Target for DM or CKD
<140/90 for all
> 18 yrs of age
Slide87
Treatment of high blood pressure
AHA 2007 guidelines: < 120/80
with LV DysfunctionCAD risk equivalents – PVD, AAA, Carotid Artery Disease
Slide88
Treatment of high blood pressure
ADA 2013 Clinical Practice
Recs:<140 SBP
<130 SBP may be appropriate for younger patients
Based on ACCORD study
Slide89
Can too low be bad?
In the elderly DBP<65 is potentially dangerous
For very elderly patients - Begin with a single drug
- Standing BP should be checked after 5 minutes
- SBP<130 & DBP<65 should be avoided
Slide90
Can too low be bad?
In the elderly DBP<65 is potentially dangerous
For elderly patients - Begin with a single drug
- Standing BP should be checked after 5 minutes
- SBP<130 & DBP<65 should be avoided
YESSlide91
Treatment of high blood pressure
What is the target?
< 140/90 …..with some caveats
Slide92
What constitutes good care?
How important is diet, exercise, weight control?What medications are available?Which ones actually work?
How low should you go?Slide93
JNC - 9
What Should We Expect?Slide94
JNC - 9
What Should We Expect?
It‘s tough to make predictions, especially about the future. Yogi BerraSlide95
JNC - 9
What Should We Expect?
SPRINT trial – target systolic 120 mmHg in nondiabetics
>
50 years.
25% lower HF/CVD & all cause mortality, Stopped due to benefit after 3.26 yrs.
N
Engl
J Med 2015:373:2103-16
Aggressive treatment of individuals with proteinuria to prevent ESRDSlide96
JNC - 9
What Should We Expect?
3. Aggressive treatment of individuals post-stroke & diabetesSlide97
What’s New
Renal Artery Denervation Slide98
Renal
Denervation
4 Trial (Phase III)Slide99
So What Do We Do Today?
Try to get most patients <140/90
Pts > 60 yrs w chronic volume depletion or susceptible to
orthostasis
<150/90 may be acceptable
Patients at high risk of CHF or CVA there appears to be benefit to decrease systolic BP to 120 with NNT of only 61 over 3
yr
period.
Slide100
Questions?Slide101
Hypertension Case Studies #1
39 YO White male with unremarkable PMH. Exam reveals an obese male with a round face and plethoric complexion.
BP 156/98 P=82 R=16/minProminent dorsal cervical and supraclavicular fat pads. Violaceous striae on trunkLab notable only for FBG = 114mg/dL
Slide102
Hypertension Case Studies #1Slide103
Hypertension Case Studies #1
What is most likely diagnosis?
A. Primary hyperaldosteronismB. PheochromocytomaC. HemochromatosisD. Cushing’s syndrome
E. Addison’s disease
Slide104
Hard to Treat Hypertension
Resistant Hypertension
Three or more medications including a diureticConsider switching to long-acting thiazideAdd Spironolactone Slide105
Hard to Treat Hypertension
Refractory Hypertension
Five or more medications including a long acting diuretic AND a mineralocorticoid receptor antagonistIn the context of normal renal perfusion, felt to be a neurogenic cause Slide106
Hypertension Case Studies #2
45 YO Female with
resistant HTN for f/u. Meds: hctz 25mg qd; lisinopril 40 mg BID; amlodipine 7.5 mg
qd
; simvastatin 40 mg
qd
PMHx
– chronic
htn
; prediabetes, LDL, 1-2 beers/d. Hypokalemia.
BP 156/98 P=82 R=16/min BMI 29.5
Serum aldosterone/plasma renin activity ratio of 31ng/
dL
per ng/mL/
hr
(
nl
<23.6)
Slide107
Hypertension Case Studies #2
What is most likely diagnosis?
A. Primary hyperaldosteronismB. PheochromocytomaC. HemochromatosisD. Alcohol Induced hypertension
E. Addison’s disease
Slide108
Resistant Hypertension Case Studies #2
Initially consider:
Nonadherence to medicationsDrug induced hypertensionWhite coat hypertensionInaccurate BP measurementsLifestyle issues (weight, Na, alcohol)Missed medical diagnoses
Slide109
Hypertension Case Studies #2
What is most likely to help?
A. Candesartan (Atacand)B. Diltiazem (Cardizem)C. Spironolactone (
Aldactone
)
D. Alcohol abstinence
E. Discontinuing simvastatin
Slide110
Hypertension Case Studies #3
52 YO White female avid scuba diver presents with stage 1 hypertension.
152/94 P=65 R=16/min BMI-23Regular exercise and history of mild hypercholesterolemia treated with diet.Given the following EKG which meds would be safe to use?Slide111
Hypertension Case Studies #3Slide112
Hypertension Case Studies #3
Amlodipine
DiltiazemAtenololClonidineChlorthalidoneACE-I / ARBSlide113
Hypertension Case Studies #4
68 YO African American male with presents with refractory hypertension presents with a history of slowly progressive confusion, irritability and forgetfulness over the last few weeks. He is otherwise active, walks his dog daily and has had no other health issues.
146/88 P=78 R=16/min BMI-27His labs including glucose, electrolytes, LFTs, CBC, are normal. Neurologic exam normal except cognitive slowing and poor short term memory.Which three of the following drugs
most likely
are contributing to his altered mental status?Slide114
Hypertension Case Studies #4
Methyldopa (
Aldomet)Propranolol (Inderal LA)
Nifedipine
(short acting)
Spironolactone
Chlorthalidone
Lisinopril
Slide115
Hypertension Case Studies #5
69 YO white female with BP 160/84.
Medical Hx notable for osteoporosis and calcium oxalate kidney stones. Which of the following drugs would be most appropriate for managing this patient’s hypertension?Slide116
Hypertension Case Studies #5
A. An ACE Inhibitor
B. An alpha-1 agonist C. A β-blockerD. A calcium channel blocker
E. A Thiazide diuretic
F. A mineralocorticoid receptor blocker
Slide117
2017Hypertension
Update
J. Paul Martin, MDSlide118
Studies
ACCORD
: Action to Control Cardiovascular Risk in Diabetes Trial 2008
– intensive BP management in diabetics didn’t improve outcome of nonfatal CV events
ALLHAT
:
Antihypertensive Lipid Lowering Treatment to Prevent Heart Attack Trial 2002
demonstrated that
chlorthalidone
is superior to ACEI, CCB, Alpha –blocker Slide119
Studies
3. HYVET
: HYpertension in the Very Elderly Trial 2008
– All cause mortality reduction 21%;
using
indapamide
/perindopril
3845 patients >80
yrs
w systolic BP
> 160
4. PROGRESS
:
Perindopril
pROtection
aGainst
REcurrent
Stroke Study 2001
demonstrated benefit of ACEI and a
thiazide
(
indapamide
).Slide120
Studies
REACH
: REduction of
Atherothrombosis
for Continued Health registry 45,000 patients:
JAMA
. 2012;308[13]:1340-1349
Among patients with either coronary artery disease (CAD) risk factors only, known prior heart attack, or known CAD without heart attack, the use of beta-blockers was not associated with a lower risk of a composite of cardiovascular events that included cardiovascular death, nonfatal heart attack or nonfatal stroke. Slide121
Studies
ONTARGET
: ONgoing
Telmisartan
Alone and in combination with
Ramipril
Global Endpoint Trial 2008:
Telmisartan
(
Micardis
) was equivalent to
ramipril
(
Altace
) with less
angioedema
. The combination provided no benefit, but more adverse effects.Slide122
Studies
ACCOMPLISH trial
: Avoiding Cardiovascular Events in Combination Therapy in Patients Living with Systolic Hypertension 2008
The
benazepril–amlodipine
combination was superior to the
benazepril
–hydrochlorothiazide combination in reducing cardiovascular events in patients with hypertension who were at high risk for such events. Slide123
Studies
COMMIT
: ClOpidogrel and Metoprolol
in Myocardial Infarction
Trial 2005 (China: 46,000
patients)
No benefit of
Metoprolol
over placebo to composite
of death,
cardiac arrest or
death from any cause during the scheduled treatment
period.