Kyle Douglas James Farber Steven Flynn Janie Gu Vivian Qin Jenny Shih Jake Silberg Anita Wamakima Through Polymer Matrices Dr David Cincotta Jeremy Tang Controlled Release Normally 1 ID: 306224
Download Presentation The PPT/PDF document "Zero-Order Controlled Release Kinetics" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Zero-Order Controlled Release Kinetics
Kyle Douglas, James Farber, Steven Flynn, Janie Gu, Vivian Qin, Jenny Shih, Jake Silberg, Anita Wamakima
Through Polymer Matrices
Dr. David Cincotta, Jeremy TangSlide2
Controlled ReleaseNormally 1st
or 2nd order0th order rare but essentialGoal: Use semipermeable membrane to keep rate of release constantSlide3
BackgroundBegan in late 1940’s & 1950’sApplications:
AgricultureZoologyCosmeticsMedicineEnvironmentSlide4
BackgroundSlide5
Membrane: PolymersSeries of repeating monomersDiverse properties:
Intermolecular forcesMolecular shapeCrystallinityUse different properties to control releasehttp://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/polymers.htmSlide6
Solubility ParametersPredict solubility of different substancesHansen solubility parameter
Equation: Ra2 = 4(δ D1 - δ D2) 2 + (δ P1 - δ
P2) 2 + (δ H1 - δ H2)
2Slide7
HypothesisPrinciple of “like likes like”Closer solubility parameters
faster diffusion rateSlide8
Polymers TestedPolyethylene (C2
H4)Ethylene-Vinyl Acetate (EVA) CopolymerVinyl Acetate (CH3COOCH=CH2)10%12%Rest is ethylene (C2H4)Slide9
Substances Released
2-PentanolEthyl AcetateHexaneMolecular
FormulaC5
H
12
O
C
4
H
8
O
2
C
6
H
14
Mass (g/mol)
88.148
88.105
86.18
Properties
Most polar
BP: 119
o
C Somewhat polar BP: 77oC Least polar BP: 69oCSlide10
ApparatusSlide11
Schematic of the ApparatusSlide12
ApparatusSlide13
DataSlide14
First-Order OutlierSlide15
Rates of EvaporationSlide16
First-Order OutlierSlide17
Statistical AnalysisANOVA’s and t
-tests indicated significant difference between data setsp < 0.05MoleculeHexane
2-PentanolEthyl Acetate
p-value
0.001
0.00004
0.00007Slide18
ConclusionZero-order release was achieved using the mechanismSolubility parameters did not account for numerous other factorsSlide19
Future StudiesMixtures of molecules (i.e. perfume)Other properties of polymers
SizeExplore solubility parameters in-depthNon-volatile substances – different apparatusSlide20
AcknowledgementsDr. David Cincotta, mentor
Jeremy Tang, assistantSig Sigamani of Celanese Corporation and Stephen Takacs, providing polymersDr. David Miyamoto, directorNJGSS and sponsors, opportunity