PPT-Kinetics of DNA Damage and Repair in Fish using the Zebrafi

Danio rerio as a model Chris A McCabe 1 Chris W Theodorakis 2 Theodore B Henry 1 and Mark G J Hartl 1 Introduction Environmental stressors can damage the DNA of aquatic organisms. MUTAGENESIS. DNA DAMAGE. DNA REPAIR. RECOMBINATION. MUTAGENESIS. Mutations. Mutations are heritable permanent changes in the base sequence of DNA.. Point mutations may be . transitions. (e.g. GC→AT) or . cellular sensing/responding, . and repair. Rebecca Fry, Ph.D.. DNA damage. DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. . DNA damage and repair and their role in carcinogenesis. A DNA sequence can be changed by copying errors introduced by DNA polymerase during replication and by environmental agents such as chemical mutagens or radiation. By: Laura Pung, Trina Morgan, Mark & Mimi Magdolen. Who Are We?. Laura Pung, Claims Manager . Wheaton|Bekins. Trina Morgan, National Account Adjuster. Wheaton|Bekins. Mark Magdolen, Repair Firm. Weathersby Guild, San Antonio-Austin. Blade Repair Service Guidance. 20 May, 2015. WindCom. . Wind Composite Services. Owned by Tecsis, 2. nd. largest wind blade producer globally.. Servicing blades since 2007.. Data base of ___________inspected and repaired blades.. and repair. Rebecca Fry, Ph.D.. DNA damage. DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. . b. y . Stephanie Amoaning-Yankson. Dr. . Adjo. Amekudzi. Georgia Institute of Technology. University Transportation Center (UTC) Conference . for the Southeastern Region. 4. th. - 5. th. April, 2013. Principles of Molecular Biology. Group Members. Maira Aleem. Bilal Naveed. Tanzeela Raza. Maheen. Malik. Zaigham. Abbas. DNA Structure. DNA = Deoxyribose nucleic . acid.. Four Nucleotides . - A. denine.  . Author: Michael Fenech. Affiliation: Genome Health Foundation, North Brighton, SA, 5048, Australia. Email: . mf.ghf@outlook.com. . Introduction. Life as we know it depends entirely on the capacity of cells to utilize energy and molecules in the environment for cellular function and reproduction. . (. Danio. . rerio. ) . as a model. Chris A. . McCabe. 1. , Chris W. Theodorakis. 2. , Theodore B. Henry. 1. and Mark G. J. . Hartl. 1. Introduction . Environmental stressors can damage the DNA of aquatic organisms. of intense freckling and high melanoma incidence, related to UV sensitivity. The syndrome actually results from defects in any of nine genes involved in repair of UV damage. C. EPAIRING DAMAGED OR A one-step DNA repair process involving an enzyme that reverts the DNA lesion to the original nucleotides. Examples are 0 6 -methylguanine DNA methyltransferase (MGMT) andphotolyases. MGMT Topic 3. DNA REPAIR. . . . S.O ANADOZIE (Ph.D.). DNA DAMAGE . DNA is the repository of genetic information in each living cell, the cellular DNA must be replicated (duplicated), maintained, and pass down to the daughter cells accuracy. . REPLICATION ERRRORS AND THEIR REPAIR. The nature of mutations. Transitions. Transversions. Some replication errors escape proofreading. Mismatch repair removes errors that escape proofreading. Structure of .