PPT-Mechanisms of DNA Damage and Repair

Principles of Molecular Biology Group Members Maira Aleem Bilal Naveed Tanzeela Raza Maheen Malik Zaigham Abbas DNA Structure DNA Deoxyribose nucleic acid Four Nucleotides A denine. Enter CPR® – Cell Phone Repair Franchise Systems, Inc. (CPR®) – an independent service organization dedicated to the on-premises repair of cell phones, iPods, and electronic devices at all of our locations from Yukon, OK, to Los Angeles, CA. At Sunny Appliance Repair, we aim to provide our customers with a complete solution to their appliance problems. whether it is a leaking refrigerator, a dishwasher that leaves stains on your glassware, or a dryer that doesn’t dry as well as you’d like it to. You don’t have to cancel your plans or sacrifice your activities in order to shop for a new appliance and install it or wait and wait until someone comes and fixes it. Nucleotide Excision Repair XP and CS. BiS222. By . Jooyoung. Chang . 장주영. Class #01 / Stu. #20091259. Assembling a Car. An analogy. Steps in building a CAR. Steps in building a . PROTEIN. Q: Most . Mechanisms for the repair of damaged DNA are probably universal. . Escherichia coli . possess 3 different mechanisms for the repair of DNA.. DNA REPAIR MECHANISMS. Excision repair. Photoreactivation. DNA damage and repair and their role in carcinogenesis. A DNA sequence can be changed by copying errors introduced by DNA polymerase during replication and by environmental agents such as chemical mutagens or radiation. Jeffrey Bryan, DVM, MS, PhD, DACVIM(Oncology). bryanjn@missouri.edu. Cellular Radiation Effects . Cell membrane - Alteration in permeability. Cellular organelles - Functional Aberrations . Nuclear membrane - Altered permeability & Function . and repair. Rebecca Fry, Ph.D.. DNA damage. DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. . Program Overview . Discussion Outline. DNA Repair. ABCs of DNA Repair. DNA Repair Defects in Cancer. DNA Repair Defects Can Be an Achilles' Heel. Synthetic Lethality and Cancer DNA Repair Defects. Increased Sensitivity of . . . cancer . development and treatment. Katsunori . Sugimoto. . nori.sugimoto. @rutgers.edu. Cancer . Abnormalities in . Proliferation . Contact inhibition. Energy . efficiency . glycolysis but not on TCA cycle.  . Author: Michael Fenech. Affiliation: Genome Health Foundation, North Brighton, SA, 5048, Australia. Email: . mf.ghf@outlook.com. . Introduction. Life as we know it depends entirely on the capacity of cells to utilize energy and molecules in the environment for cellular function and reproduction. . (Chapter 12). Presented by Dr. Laurie M. Erickson. Chair of the Department of Health Sciences. Blitstein Institute of Hebrew Theological College. Chicago, IL, USA.. 12.1-12.2 Mutations . Mutation:. any heritable change in the genetic material. If we have an error one in a million this mean we will have 3000 errors during each replication cycle of the genome.. The genome of a typical mammalian cell . accumulates many . thousands of lesions during a 24-hour period.. of intense freckling and high melanoma incidence, related to UV sensitivity. The syndrome actually results from defects in any of nine genes involved in repair of UV damage. C. EPAIRING DAMAGED OR A one-step DNA repair process involving an enzyme that reverts the DNA lesion to the original nucleotides. Examples are 0 6 -methylguanine DNA methyltransferase (MGMT) andphotolyases. MGMT