PPT-Mechanisms of DNA Damage and Repair

Principles of Molecular Biology Group Members Maira Aleem Bilal Naveed Tanzeela Raza Maheen Malik Zaigham Abbas DNA Structure DNA Deoxyribose nucleic acid Four Nucleotides A denine. Jeffrey Bryan, DVM, MS, PhD, DACVIM(Oncology). bryanjn@missouri.edu. Cellular Radiation Effects . Cell membrane - Alteration in permeability. Cellular organelles - Functional Aberrations . Nuclear membrane - Altered permeability & Function . MUTAGENESIS. DNA DAMAGE. DNA REPAIR. RECOMBINATION. MUTAGENESIS. Mutations. Mutations are heritable permanent changes in the base sequence of DNA.. Point mutations may be . transitions. (e.g. GC→AT) or . cellular sensing/responding, . and repair. Rebecca Fry, Ph.D.. DNA damage. DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. . Nucleotide Excision Repair XP and CS. BiS222. By . Jooyoung. Chang . 장주영. Class #01 / Stu. #20091259. Assembling a Car. An analogy. Steps in building a CAR. Steps in building a . PROTEIN. Q: Most . Mechanisms for the repair of damaged DNA are probably universal. . Escherichia coli . possess 3 different mechanisms for the repair of DNA.. DNA REPAIR MECHANISMS. Excision repair. Photoreactivation. DNA damage and repair and their role in carcinogenesis. A DNA sequence can be changed by copying errors introduced by DNA polymerase during replication and by environmental agents such as chemical mutagens or radiation. (. Danio. . rerio. ) . as a model. Chris A. . McCabe. 1. , Chris W. Theodorakis. 2. , Theodore B. Henry. 1. and Mark G. J. . Hartl. 1. Introduction . Environmental stressors can damage the DNA of aquatic organisms. Jeffrey Bryan, DVM, MS, PhD, DACVIM(Oncology). bryanjn@missouri.edu. Cellular Radiation Effects . Cell membrane - Alteration in permeability. Cellular organelles - Functional Aberrations . Nuclear membrane - Altered permeability & Function . By: Laura Pung, Trina Morgan, Mark & Mimi Magdolen. Who Are We?. Laura Pung, Claims Manager . Wheaton|Bekins. Trina Morgan, National Account Adjuster. Wheaton|Bekins. Mark Magdolen, Repair Firm. Weathersby Guild, San Antonio-Austin. and repair. Rebecca Fry, Ph.D.. DNA damage. DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. . (. Danio. . rerio. ) . as a model. Chris A. . McCabe. 1. , Chris W. Theodorakis. 2. , Theodore B. Henry. 1. and Mark G. J. . Hartl. 1. Introduction . Environmental stressors can damage the DNA of aquatic organisms. A one-step DNA repair process involving an enzyme that reverts the DNA lesion to the original nucleotides. Examples are 0 6 -methylguanine DNA methyltransferase (MGMT) andphotolyases. MGMT Topic 3. DNA REPAIR. . . . S.O ANADOZIE (Ph.D.). DNA DAMAGE . DNA is the repository of genetic information in each living cell, the cellular DNA must be replicated (duplicated), maintained, and pass down to the daughter cells accuracy. . REPLICATION ERRRORS AND THEIR REPAIR. The nature of mutations. Transitions. Transversions. Some replication errors escape proofreading. Mismatch repair removes errors that escape proofreading. Structure of .