PPT-Lecture 5: Mutation and DNA Repair

Chapter 12 Presented by Dr Laurie M Erickson Chair of the Department of Health Sciences Blitstein Institute of Hebrew Theological College Chicago IL USA 121122 Mutations Mutation any heritable change in the genetic material. A. frameshift. B. missense. C. neutral. D. silent. E. transition. REEF Question. A normal 90 . bp. length of DNA gives rise to a 30 amino acid polypeptide after transcription and translation. An A. G. by Dr. . Sawsan. . Saijd. . 1-Post replication events. 2- DNA repair and proofreading activity . While DNA replication errors are rare, they must be corrected by various DNA repair pathways.. . Post. and repair. Rebecca Fry, Ph.D.. DNA damage. DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. . Carolyn Keeton. Turn In HW 1 in Front. Outline. What causes mutations?. Spontaneous. Mutator Strains. Mutagens. Considerations. Isolation of Mutants . Selections. Screens. Enrichments. Transitions vs. . Twelfth Edition. Chapter 12. Gene Mutation. © McGraw-Hill Education. All rights reserved. Authorized only for instructor use in the classroom. No reproduction or further distribution permitted . without . Post replication events. DNA . proofreading and . repair activity . While DNA replication errors are rare, they must be corrected by various DNA repair pathways.. . Post replication events : DNA methylation . Conditional mutations. Point mutations. In . point mutations . the sequence of the DNA has been altered at a single position. Where this change consists of replacing one nucleotide by another, it is known as a . Asst. Prof. Dr. . Dalya. Basil Hanna . In this lecture…... Mutation:. Gene (point) Mutation. Chromosomal Mutation. Gene Mutation . A gene mutation occurs when the nucleotide sequence of the DNA is altered and a new sequence is passed on to the offspring. The change may be either a substitution of one or a few nucleotides for others or an insertion or deletion of one or a few pairs of nucleotides. Mutations. and . polymorphisms. Genetics. and . genomics. ED . 01. . March. . 20. 19.. 2. Geneti. c . variability. I. ncreased. . by . - . S. exual. . reproduction . meiosis (generation of gametes. of intense freckling and high melanoma incidence, related to UV sensitivity. The syndrome actually results from defects in any of nine genes involved in repair of UV damage. C. EPAIRING DAMAGED OR ODU. Reading for Next Class:. Chapter 3, Russell and . Norvig. Applications of Genetic . Algorithms. Special thanks to Dr. . Yaohang. Li for contributing the slides. Review. Last Class. Introduction to Genetic Algorithm. Is a natural process that changes a DNA sequence.. Mutant or Mutation – to describe something undesirable or broken.. Rarely cause death or disease. Generates new variations that can give an individual a survival advantage.. Topic 3. DNA REPAIR. . . . S.O ANADOZIE (Ph.D.). DNA DAMAGE . DNA is the repository of genetic information in each living cell, the cellular DNA must be replicated (duplicated), maintained, and pass down to the daughter cells accuracy. . Julianne O’Daniel, MS, CGC. Joan Scott, MS, CGC. Elizabeth . Varga. , MS, CGC. VO Speights, DO. Erynn. Gordon, MS, CGC. March 2012. TRiG Curriculum: Lecture 4. 1. What will be the pathology report of the future?.