PPT-PARP and Other DNA Damage Repair Inhibitors in Solid Tumors: An Update

Program Overview Discussion Outline DNA Repair ABCs of DNA Repair DNA Repair Defects in Cancer DNA Repair Defects Can Be an Achilles Heel Synthetic Lethality and Cancer DNA Repair Defects Increased Sensitivity of . Enter CPR® – Cell Phone Repair Franchise Systems, Inc. (CPR®) – an independent service organization dedicated to the on-premises repair of cell phones, iPods, and electronic devices at all of our locations from Yukon, OK, to Los Angeles, CA. Enter CPR® – Cell Phone Repair Franchise Systems, Inc. (CPR®) – an independent service organization dedicated to the on-premises repair of cell phones, iPods, and electronic devices at all of our locations from Yukon, OK, to Los Angeles, CA. cellular sensing/responding, . and repair. Rebecca Fry, Ph.D.. DNA damage. DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. . Nucleotide Excision Repair XP and CS. BiS222. By . Jooyoung. Chang . 장주영. Class #01 / Stu. #20091259. Assembling a Car. An analogy. Steps in building a CAR. Steps in building a . PROTEIN. Q: Most . DNA damage and repair and their role in carcinogenesis. A DNA sequence can be changed by copying errors introduced by DNA polymerase during replication and by environmental agents such as chemical mutagens or radiation. (. Danio. . rerio. ) . as a model. Chris A. . McCabe. 1. , Chris W. Theodorakis. 2. , Theodore B. Henry. 1. and Mark G. J. . Hartl. 1. Introduction . Environmental stressors can damage the DNA of aquatic organisms. Begin . Dermoid. cyst. Mucocele. Hemangioma. Lymphangioma. Malignant . rabdomyosarcoma. Benign tumors of the orbit . can develop from infancy and grow rapidly or slowly. It can be superficial and easily identifiable by external presentation, palpation and x – rays or CT scan . Niraparib. and . Temozolomide. in Patients with Previously Treated, incurable Ewing Sarcoma . Co-Principal Investigators: . Sandra . Strauss, MD, PhD. University College London. Rashmi. . Chugh. , MD. This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States and data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.. PARP Inhibitors: What Do We know?. PARP Inhibitors: What Do We Know? (cont). PARP Inhibitors: What Don't We Know ?. SOLO-1: Study Rationale and Design. [a]. Primary Endpoint and Other . R. esults. Time to Second Progression or Death (. DNA damage DNA gets damaged a lot ! DNA damage DNA gets damaged a lot! >200,000 events/human cell/day DNA damage Occurs 2 ways 1) spontaneously 2) mutagens : damage DNA Transposons Discovered by Barbara McClintock Begin . Dermoid. cyst. Mucocele. Hemangioma. Lymphangioma. Malignant . rabdomyosarcoma. Benign tumors of the orbit . can develop from infancy and grow rapidly or slowly. It can be superficial and easily identifiable by external presentation, palpation and x – rays or CT scan . Five-year . survival. 15%. 30%. 40%. ?50%?. First use . of . cisplatin. First use . of . carboplatin. First use . of . Paclitaxel . First reports . of. bevacizumab. Positive evidence . for weekly paclitaxel in first line. If we have an error one in a million this mean we will have 3000 errors during each replication cycle of the genome.. The genome of a typical mammalian cell . accumulates many . thousands of lesions during a 24-hour period..