cerebral vascular disease clinical and preclinical Mechanisms key topics outline by guest speakers Endothelial related mechanisms White matter inflammation and hypoxia ID: 1042576
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1. Introduction and background to cerebral vascular disease(clinical and pre-clinical)Mechanisms (key topics)(outline by guest speakers)Endothelial related mechanisms White matter, inflammation and hypoxia Modelling the NVU in vitroExtracellular matrix proteins Perivascular drainage pathways Neuro-glial-vascular mechanismsThemed Discussion Groups (10-12 participants/group)Experimental models Blood brain barrier and endothelial related dysfunctionHypoperfusion/ischaemiaWhite matterDrainage pathwaysInflammatory mechanisms /interactions with systemic circulationNeuro- glial - vascular mechanisms Feedback from each discussion groupGaps and opportunities identified Workshop proceedingsImproving translation (key topics) (outline by guest speakers)Experimental design of animal studies Measuring behavioural outcomes Multicentre preclinical studies Themed Discussion Groups (10-12 participants/group)Improving translation including relevant biomarkers Sharing, model exchange and potential tissue banks Multicentre studies in experimental models of SVD