PPT-Insulin Sensitivity and β-cell

Function in Adult Nigerians with Sickle Cell Anaemia Akinlade KS 1 Adewale CO 1 Fasola FA 2 Rahamon SK 1 Dada VO 3   1 Department of Chemical Pathology 2 Department of Haematology College of Medicine University of Ibadan . Pharmacoepidemiology and Drug Safety. 2008;(17):753-759.. So benefit of both SU/Insulin in. research studies –UKPDS, DCCT/EDIC. But adverse risk in ‘real world’ use. Link between hypoglycemia and acute cardiovascular events in type 2 diabetes. 24. th. November 2016. Andrew Gallagher. Consultant Physician. and Endocrinologist. NHS Greater Glasgow & Clyde. Prevalence – 2015 data. WORLDWIDE. . Almost 300 million people with diabetes aged 20-79. Data. Lijing Wang. 1. , . Yangzhong. . Tang. 2. , . Stevan. . Djakovic. 2. , . Julie . Rice. 2. , . Tony . Wu. 2. , . Daniel J. . Anderson. 2. , . Yuan . Yao. 3. DahShu. Data Science Symposium: Computational Precision Health . (except in . Ketosis-prone). Vicious . Circle(s) of Hyperinsulinemia-. Result in Weight Gain and Hypoglycemia. Hypoglycemia. Symptomatic or not!. Or . bolus Insulin. =. Overinsulinized. Undue Basal . T1DM- LIKE autoimmune diabetes- . I. nsulitis . The . class I MHC molecules are . hyperexpressed. on the β-cell surface in T1D patients making β-cells more . susceptible to cytotoxic lymphocyte (CTL)-mediated destruction. . Pharmacoepidemiology and Drug Safety. 2008;(17):753-759.. So benefit of both SU/Insulin in. research studies –UKPDS, DCCT/EDIC. But adverse risk in ‘real world’ use. Link between hypoglycemia and acute cardiovascular events in type 2 diabetes. . Intuitively obvious approach. …. ANSWERS THE CALL TO ACTION. ALL DM = Hyperglycemia. Classify. each patient by the . specific cause(s. ) of the . β. -cell dysfunction in the clinical presentation of their disease. Rutherford Appleton Laboratory. University of Oxford. University of Sussex. ILL. University of Kure. Technology. Neutrons. in. HV in. Sensitivity. (NB sensitivity/day is actually closer to ). 2+ . Sensors and Integration with Microphysiological Systems. Emma L. McBride*. 1,2. , James Nolan*. 3. , . Hyowon. Hugh Lee. 3. , Sherry L. Harbin. 1,4. 1. 1. Weldon School of Biomedical Engineering, College of Engineering, Purdue University. Beta Cells in the Pancreas. Insulin is synthesized in beta cells. Insulin helps to regulate metabolism of carbohydrates and fats. Insulin is secreted by the pancreas. Without insulin to facilitate absorption of glucose the levels become too high. (1992) 35 Suppl 2: S 41~S 48 and molecular biology of the Beta cell group chairman: D. F. Steiner 1 Report prepared by: D. E. James 2 1 Howard Hughes Medical Institute, Chicago, Illinois, and 2 Dep Insulin 5-ethynyl-2  - Pancreas Embryonic stem cell �&�G.�P�K�V�K�X�G endoderm �.�K�X�G�T Acinar cell Duct cell  -cell  -cell  -cell PP c November 2016. Andrew Gallagher. Consultant Physician. and Endocrinologist. NHS Greater Glasgow & Clyde. Prevalence – 2015 data. WORLDWIDE. . Almost 300 million people with diabetes aged 20-79. : The Untapped Diagnostic Tool in Nigeria. BY. HAUWA BAKO. @ . 23. rd. National Conference . of the . Guild of Medical Laboratory Directors, Nigeria. 17. th. -20. th. August, 2021. 1. INTRODUCTION.