Nausea can be a distressing symptom of migraine and one that is feared by patients 1 There are many different antiemetic agents with various mechanisms of action that can reduce the feeling of nausea in some patients ID: 1006565
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1. MigraineAdjunct treatment - Antiemetics (anti-nausea agents)Nausea can be a distressing symptom of migraine, and one that is feared by patients1.There are many different antiemetic agents, with various mechanisms of action, that can reduce the feeling of nausea in some patients1,2.A Cochrane analysis found that a certain antiemetic drug improved the relief of migraine-related nausea and vomiting when combined with analgesic medication3.Furthermore, there is some evidence that combining a certain antiemetic agent with triptan therapy improves the efficacy of the triptan, although more research is needed4,5.In general, certain antiemetic therapies are often recommended as part of combination therapy for patients experiencing severe nausea related to migraine attacks5,6.5-HT=5-hydroxytryptamine (serotonin)1. Lyons & Ballisat. Update Anaesthesia 2016;31:38–42; 2. Hauser et al. Antiemetic Medications. 2020; 3. Kirthi et al. Cochrane Database Syst Rev 2013;(4):CD008041; 4. Schulman & Dermott. Headache 2003;43(7):729–733; 5. Worthington et al. Can J Neurol Sci 2013;40(5 Suppl 3):S1–S80; 6. Marmura et al. Headache 2015;55(1):3–20