PPT-Randomized Phase II Workshop

Wendy Parulekar MD FRCPC Wei Tu PhD Objectives To review the classification of randomized phase II trial designs To propose and critique potential  randomized phase II trials designs for a concept in head and neck cancer case scenario to be presented. Randomiza tion if done properly can keep study groups as similar as possible at the outset so that the investigators can isolate and quantify the effect of the interventions they are studying No other study design gives us the power to balance unkno 005 p0005 p0005 p0013 p0013 p0013 25 25 25 20 20 20 15 15 15 10 10 10 5 5 5 0 0 0 5 5 5 01 01 01 2345678 2345678 2345678 Change in UDysRS Score LS Mean SE Change in UDysRS Score LS Mean SE Change in UDysRS Score LS Mean SE Weeks Weeks Weeks Placeb Impact Evaluation Methods for Policy Makers. This material constitutes supporting material for the "Impact Evaluation in Practice" book. This additional material is made freely but please acknowledge its use as follows: . Michael Ben-Or. The Hebrew University. Michael Rabin’s Birthday Celebration. Randomized Protocols. Power of Randomization. Exponential . speedup for known algorithms. Complexity . – The jury is still out . 1. , Dragi Kocev. 2. , . Suzana Lo. skovska. 1. , . Sašo Džeroski. 2. 1. Faculty of Electrical Engineering and Information Technologies, Department of Computer Science, Skopje, Macedonia. . 2. . CS648. . Lecture 17. Miscellaneous applications of . Backward analysis. 1. Minimum spanning tree. 2. Minimum spanning tree. . 3. b. a. c. d. h. x. y. u. v. 18. 7. 1. 19. 22. 10. 3. 12. 3. 15. 11. 5. CS648. . Lecture . 25. Derandomization. using conditional expectation. A probability gem. 1. Derandomization. using . conditional expectation. 2. Problem 1. : Large cut in a graph. Problem:. Let . CS648. . Lecture 4. Linearity of Expectation with applications. (Most important tool for analyzing randomized algorithms). 1. RECAP from the last lecture. 2. Random variable. Definition. :. . A random variable defined over a probability space (. Quicksort. . [CLRS, kapitel 7]. Gerth Stølting Brodal. Sandsynligheden for at slå krone. 1/2. Quicksort:. Sorter . A. [. p. ... r. ]. Hoare, 1961. Worst-case tid . O(. n. 2. ). A. p. r. x. A. p. r. Data Collection: . Experiments and Observational Studies. 1/23/12. Association. versus Causation. Confounding Variables. Observational Studies . vs. Experiments. Randomized Experiments. Section 1.3. Neighborhood. Hill Climbing. : Sample p points randomly in the neighborhood of the currently best . solution; determine the best solution of the n sampled points. If it is better than the . current solution, make it the new current solution and continue the search; otherwise, . This material constitutes supporting material for the "Impact Evaluation in Practice" book. This additional material is made freely but please acknowledge its use as follows: . Gertler. , P. J.; Martinez, S., . What is an Experiment?. Campbell & Stanley stressed random assignment to experimental treatments.. I stress manipulation of the independent variable.. Quasi-Experiments: C&S’s term for research where. Experiments and Observational Studies. 1/23/12. Association. versus Causation. Confounding Variables. Observational Studies . vs. Experiments. Randomized Experiments. Section 1.3. Professor Kari Lock Morgan.