PPT-Antihistamines

By Jean Collado Before Learning About Antihistamines We must learn about histamine Histamine is an organic nitrogen compound involved with our immune system It was discovered in 1910 by Henry Dale and Patrick Laidlaw. CLARITIN launched as an OTC in 1990 and by the mid 90s was market leader Editor s note see CASSIES I In early 1995 Reactine took the OTC route It was the 1 prescription drug and it invested massively in launch advertising outspending CLARITIN 21 By 16 Supplement 1312 2006 Esmon Publicidad Comparative pharmacology of the H antihistamines First Chlorpheniramine 28 08 3 Diphenhydramine 17 10 2 Doxepin 2 na Hydroxyzine 21 04 2 Acrivastine 14 04 1 Ketotifen 36 16 na Cetirizine 10 05 1 Lorat Church MD and Martin K Church PhD DSc Abstract This article reviews the molecular biology of the inter action of histamine with its H receptor and describes the concept that H antihistamines are not receptor antagonists but are inverse agonists ie t Estelle R Simons 57511 and Keith J Simons Abstract In this review we compare and contrast the clinical pharmacology ef64257cacy and safety of 64257rstgeneration H antihista mines and secondgeneration H antihistamines Firstgeneration H antihista Hospital de Basurto Bilbao Spain Unitat de Rinologia Servei dOtorinolaringologia ICEMEQ Hospital Clnic Barcelona Spain Unitat dAllrgia Servei de Pneumologia i Allrgia Respiratria Hospital Clnic ICT Barcelona Spain Clnica Dr Lobatn Cdiz Spain Servici Copyright Regulations 1969. WARNING. This material has been copied and communicated to. . you by or on behalf of the University of Sydney. . pursuant to Part VB of the Copyright Act 1968. . (The Act).. Dr K Outhoff. Contents. Allergic Rhinitis. Nasal furunculosis. Epistaxis. Local anaesthetic drugs. Rhinosinusitis. Viral. Bacterial. Fungal. Iatrogenic conditions. A. Nasal Obstruction. Viral URTI . Drugs for stuffy nose, sinus trouble, congestion, and the common cold constitute the largest segment of the over - the - counter market for America's pharmaceutical industry. When used wisely, they Antihistamines.Antihistaminesmedicationspreventandincludingrunny steroidsprays.reduceinflammationyour preventrunnyMedicationstemporaryandcorrectRepair(septoplasty)experiencebothersomesignificantchroni Histamine. To understand antihistamines you have to slightly understand what it is blocking. Histamine. There are 4 different histamine receptors. H. 1. – H. 4. We will be focusing on H1. H1 receptors are located in the lower respiratory tract and skin. . What is Rhinitis?. The nasal passages are lined with a membrane that produces mucus. Mucus is one of the body's defense systems:. Thin clear liquid, traps small particles and bacteria . The trapped bacteria usually remain harmless in healthy individuals. Stacey Jean. Kiara Whipple. Darla Beliziaire. Christina Fleury. Jaqua’Jah Frederick. Upper Respiratory. Drug Class: . Antihistamines. Action. Antihistamines, or H1-receptor antagonists, are chemical agents that act by competing with the allergy-liberated histamine for H1-receptor sites . Histamine. Endogenous compound. Found in specialized cells. Important role in:. Allergic reaction. Regulation of . gastric acid secretion. Histamine use limited to diagnostic procedures. Histamine. Distribution. Histamine is an autacoid chemical messenger mostly generated in mast cells that mediates a wide range of cellular responses, including allergic and inflammatory reactions, gastric acid secretion, and neurotransmission in parts of the brain. .