Program Overview PAH Diagnostic Tools PAH Importance of Early Diagnosis to Improve Patient Outcomes Diagnostic Algorithm for PH Echocardiographic Probability of PH in Symptomatic Patients With a Suspicion of PH ID: 530292
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EARLY Combination Therapy in PAH: What Every Cardiologist Needs to KnowSlide2Slide3
Program OverviewSlide4
PAH Diagnostic Tools Slide5
PAH: Importance of Early Diagnosis to Improve Patient Outcomes Slide6
Diagnostic Algorithm for PHSlide7
Echocardiographic Probability of PH in Symptomatic Patients With a Suspicion of PHSlide8
Other Echocardiographic PH SignsSlide9
PAH Diagnostic Tools (cont) Slide10
Hemodynamic Definitions of PH as Assessed by RHC Slide11
Hemodynamic Parameters Measured or Derived From RHCSlide12
PAH Treatment: General StrategySlide13
PAH Treatment: General MeasuresSlide14
PAH Treatment: Supportive Therapy Slide15
PAH Treatment: Specific Drug TherapySlide16
Prognostic Evaluation and Risk AssessmentSlide17
Initial Combination Therapy for High-Risk Patients With PAHSlide18
Initial Combination Therapy for Low/Intermediate-Risk Patients With PAHSlide19
Initial Use of Ambrisentan Plus Tadalafil in PAH: The AMBITION Trial Slide20
AMBITION Trial: Primary Endpoint* ResultsSlide21
ERS/ESC Evidence-Based Treatment Algorithm for Patients With PAHSlide22
PAH Therapies Target Diverse Vasomotor PathwaysSlide23
Combination Therapy in PAH: Rationale and Potential Clinical BenefitsSlide24
Role of Monotherapy for the Treatment of PAHSlide25
Pathobiology of PAHSlide26
Initial Combination Therapy for the Treatment of PAHSlide27
AMBITION: Efficacy ResultsSlide28
AMBITION Primary Endpoint* Results by Subgroup Slide29
Initial vs Sequential Combination Therapy: How to Choose?Slide30
Follow-Up Strategy for Patients With PAHSlide31
ConclusionsSlide32
Conclusions (cont)Slide33
AbbreviationsSlide34
Abbreviations (cont)Slide35
Abbreviations (cont)Slide36
Abbreviations (cont)