Analytical Observational Studies The purpose of an analytic study in epidemiology is to identify and quantify the relationship between an exposure and a health outcome The hallmark of such a study is the presence of at least two groups one of which serves as a comparison group ID: 911200
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Slide1
Study Design
Analytical Observational Studies
Slide2Analytical Observational Studies
The purpose of an analytic study in epidemiology is to identify and quantify the relationship between an exposure and a health outcome. The hallmark of such a study is the presence of at least two groups, one of which serves as a comparison group.
Slide3Analytical Observational Studies
Observational studies are those in which individuals are observed and their outcomes are measured by the investigators.
Interventional studies are those in which the research subjects are assigned by the investigator to a treatment or other intervention, and their outcomes are measured.
Slide4Analytical Observational Studies
Analytical observational studies can be of three types, depending on the time sequence and sampling procedures used to collect data.
Slide5Time is Key
The Cohort (Prospective) design measures exposure in the present and the disease in the future.
The Case-Control (Retrospective) design measures the disease in the present and looks backwards for exposure history.
The simplest is the Cross-Sectional (Prevalence) design which is conducted completely at present.
From: Miller School of Medicine, University of Miami
http://
hihg.med.miami.edu/code/http/modules/education/Design/Print.asp?CourseNum=4&LessonNum=4
Slide6Cross-Sectional Study
Cross-Sectional studies can be descriptive or analytical.
In analytical cross-sectional studies, data on the prevalence of both exposure and a health outcome are obtained for the purpose of comparing health outcome differences between exposed and unexposed.
Slide7Cross-Sectional Study
Analytical studies attempt to describe the prevalence of, for example, disease or non-disease by first beginning with a population base.
These
studies differ from solely descriptive cross-sectional studies in that they compare the
proportion of exposed
persons who are diseased
with
the proportion of non-exposed persons who are
diseased.
Slide8Cross-Sectional Study
From: Cross-Sectional Study,
http://www.hsrmethods.org
Slide9Case Control Study
Are studies in which patients who already have a specific condition
are compared with people who do not have the condition. The researcher looks back to identify factors or exposures that might be associated with the illness.
Slide10Case Control Study
They often rely on medical records and patient recall for data collection. These types of studies are often less reliable than randomized controlled trials and cohort studies because showing a statistical relationship does not mean that one factor necessarily caused the other.
Slide11Case Control Study
For example, 50 people in Chatham County come to the hospital and are found to have Type 2 Diabetes. 44 of them live in downtown Savannah. You conclude that living in downtown Savannah causes Type 2 Diabetes.
Slide12Case-Control Study
From:
Prehospital Research
Support site,
http://prehospitalresearch.eu/?
p=1961
Slide13Cohort Study
Cohort Studies take a large population and follow patients who have a specific condition or receive a particular treatment over time and compare them with another group that has not been affected by the condition or treatment being studied.
Slide14Cohort Study
From:
Suny
Downstate Medical Center, Evidence Based
Medicine Tutorial,
http://
library.downstate.edu/EBM2/2400.htm
Slide15Prospective Cohort Study
Prospective
: none of the subjects have the disease (or other outcome) being measured when the study commences; data analysis happens after a period of time has elapsed.
A prospective cohort study takes a group of similar people (a cohort) and studies them over time. At the time the baseline data is collected, none of the people in the study have the condition of interest.
Slide16Prospective Cohort Study
Prospective example: a group of 100 people with high risk factors for AIDS are followed for 20 years to see if they develop the disease. A control group of 100 people who have low risk factors are also followed for comparison.
Slide17Retrospective Cohort Study
Retrospective (Historical): the researcher looks at historical data for a group. Some of the people in this group have developed the disease, and some have not. This can result in finding out who has the disease and when they developed it.
Slide18Retrospective Cohort Study
Retrospective example: a group of 100 people with AIDS might be asked about their lifestyle choices and medical history in order to study the origins of the disease. A Second group of 100 people without AIDS are also studied and the two groups are compared.
Slide19Question
A researcher interested in the relationship between vaccination and autism sends a survey to parents of children who are active patients at a large primary care practice. The survey asks several questions, including whether their children received their childhood vaccines on-time, and whether their children currently have a diagnosis of an autism spectrum disorder. Which of the following correctly identifies the study design used by the researcher?
Case Control Study
Cross Sectional Study
Prospective Cohort Study
Retrospective Cohort Study
Slide20Answer
Cross Sectional StudyThe researcher used a cross-sectional study design by measuring both the exposure (vaccination) and the outcome (autism spectrum disorder diagnosis) simultaneously.
Slide21Question
A study was designed to assess the impact of sun exposure on skin damage in beach volleyball players. During a weekend tournament, players from one team wore waterproof, SPF 35 sunscreen, while players from the other team did not wear any sunscreen. At the end of the volleyball tournament players' skin from both teams was analyzed for texture, sun damage, and burns. Comparisons of skin damage were then made based on the use of sunscreen. The analysis showed a significant difference between the cohorts in terms of the skin damage. Which of the following correctly identifies the study design used by the researcher?
Case Control Study
Cross Sectional Study
Prospective Cohort Study
Retrospective Cohort Study
Slide22Answer
Prospective Cohort StudyA group of similar people (volleyball players) were selected. At the time the baseline data is collected, none of the people in the study have the condition of interest. The study measures exposure in the present and the condition in the future.