PPT-Adaptive Trial Designs

Global Forum on Bioethics in Research Emerging Epidemic Infections and Experimental Treatments November 4 2015 Lord Kelvin I often say that when you can measure what you are speaking about and express it in numbers you know something about it but when you cannot measure it when you cannot express it in numbers your knowledge is of a meagre and unsatisfactory kind it may be the beginning of knowledge but you have scarcely in your thoughts advanced to the state of Science whatever the matter may be. Applications in Plant Breeding. Jennifer Kling. Oregon State University. Outline – Augmented Designs. Essential features. When are they used in plant breeding?. Design options. Today - one-way . control of . Production Engineered Designs (PED) is a highly experienced innovation consultant firm with global resources in design. manufacturing, engineering & technology transfer. PED’s mission is to turn innovation into manufacturable, cost competitive and user friendly products. http://www.ped-inc.com/ John Roberto. LifelongFaith Associates. (jroberto@lifelongfaith.com). Leadership . is . the . activity of mobilizing people to tackle . tough challenges (problems) . and do the adaptive work necessary to achieve . Danica Adams. Adaptive capacity. is one way to measure . resilience. .. Adaptive capacity. . is . the ability of a system . – in this case, Vermilion Parish as a political unit – . to adapt to changing circumstances while still retaining its fundamental functions as a system. . Adaptive Management. 2. Growth. Recruitment. Stock or. Biomass. Natural. Harvest. Risk. Assessment. Economics. Sociocultural. Political/Legal. Management. Objectives. Management. Actions. Stock. Assessment. Patti L. Harrison, PhD, and Thomas Oakland, PhD. Overview. Useful for diagnosing and classifying various developmental, learning, and behavioral disabilities and disorders; identifying you clients’ strengths and weaknesses; and documenting and monitoring progress over time, the ABAS-3 provides a comprehensive norm-referenced assessment of adaptive skills.. Mahesh Parmar. MRC . Clinical Trials Unit at . UCL. Rationale . for adaptive trials. Our . adaptive trials and their setting. Discuss some broad practical and statistical challenges. Offer some solutions and thoughts. IV External Validity Non-randomised controlled trial. Randomised controlled trial . Parallel group. Cross-over. Single or double blind. Superiority or non-inferiority trial. 2. Trial design types. In a clinical trial design, there are a number of different types of comparisons that can be included:. D. esigns. 2. Steps in clinical . d. evelopment . p. rograms. Phase I:. . Studies on . dosing. Phase . III:. . Assess . therapeutic effect and benefit-risk in patients of candidate vs. standard of . What you should know about study design. Demonstrated on . Head of Statistics. nQuery. Lead Researcher. FDA Guest Speaker. Guest Lecturer. Webinar Host. HOSTED BY: . Ronan Fitzpatrick. AGENDA. Adaptive Designs in Confirmatory Trials. John Scott, Ph.D.. Director, Division of Biostatistics. Office of Biostatistics and Epidemiology. Center for Biologics Evaluation and Research. FDA. Disclaimer. This presentation reflects the views of the author and should not be construed to represent FDA’s views or policies. &. . Oversight. . of . clinical. . trials. Dr Greg Fox. University. of Sydney, . Australia. Outline. Cluster Randomized and stepped wedged intervention trials. Ethical standards in clinical trials. B. rain . I. njury . T. reatment Trial: A Multicenter Phase II Adaptive Clinical Trial. . Gaylan. . Rockswold. , MD, PhD, Principal Investigator. Thomas Bergman, MD, Site Principal Investigator. Overview.