PPT-Mendelian Traits in YOU!

The presence of middigital hair is a dominant condition therefore those lacking it are homozygous recessive Middigital Hair Freckles Freckles are small concentrated spots of a skin pigment called melanin Most fairskinned redhaired people have them. Heredity. CH12 . pg. 267. Sexual Reproduction. Combining of a sperm cell and an egg cell from two individuals . The offspring of this "cross" will have characteristics from both "parents“. hybrid. Mendelian. Genomics. www.mendelian.org. gmendel@mendelian.org. Goal: Identify and define the causes of all human . monogenic diseases. Explain human biology. Allow diagnostic testing important for disease prevention, therapy and prognosis. (Fundamentals of Genetics). Chapter 9. Heredity. The transmission of characteristics from parent to offspring. . Trait (allele)- variant of a characteristic. Mendel observed 7 characteristics of pea plants.. David Evans. Some Criticisms of GWA Studies…. So you have a new GWAS hit for a disease… so what!?. You can’t change people’s genotypes (at least not yet). You can however modify people’s environments…. Exome. sequencing identifies the cause of a . Mendelian. disorder.. Nat. Genet. 42, 30–35 (2010).. Cupped ears. coloboma. of the lower eyelids, . prominent . nose, . micrognathia. . absence . of the fifth digits of the feet. 1. Family resemblance: your mother and father each contribute to your genetic makeup.. allele:. alternative version of a gene. 2. Family resemblance: your mother and father each contribute to your genetic makeup.. David Evans. University of Queensland. University of Bristol. Some Criticisms of DOC Modelling in Twins. Measurement error. Power (both variables need to have radically different aetiologies). Only useful for testing strong hypotheses about causation. Oregon State University. A . trait. is a measurable feature or behavior of an organism; it can have multiple . phenotypes. “attached” earlobe. “detached” earlobe. Some traits are more discrete, others continuous. Tongue Rolling. T- tongue roller. Dominant. Tt or TT. t - non-roller. Recessive. tt. Attached Earlobes. E- Earlobes. Dominant. EE or Ee. e- no earlobes. Recessive. ee. Interlocking Fingers. I- interlocking fingers (left thumb). Genetics. Biology. . Genetics. . - . The . study of heredity, how traits are passed from parent to offspring. x. =. or. or. The study of heredity started . with the work of . Gregor. Mendel. and his . Set your view settings to “Speaker View” to better see who is talking. Keep your microphone muted (camera optional) outside of breakout rooms.. Feel free to use the chat to let us know:. where you’re joining from. Genomics Lesson 12_1. Ross . Hardison. 4/19/15. 1. Genetic association. The occurrence together in a population, more often than can be readily explained by chance, of two or more traits of which at least one is known to be genetic.. Gregor Mendel:. 1823-1884. 2. Genetics. Genetics. . is the Study of heredity (the transmission of traits from generation to generation).. . Genetics began with the work of . Gregor. Mendel. Mendel developed basic principals of heredity with . multifactorial traits affected research into Mendelian disorders? Stylianos E. Antonarakis. For about a century, the argument for focusing on rare Mendelian disorders was as follows: Mendelian ph