No aspirin n 7335 JPPP Primary endpoint CV deathMIstroke for aspirin vs no aspirin 28 vs 30 p 054 CV death 086 vs 078 p 089 nonfatal cerebrovascular disease 165 ID: 764416
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No aspirin(n = 7,335) JPPP Primary endpoint (CV death/MI/stroke) for aspirin vs. no aspirin: 2.8% vs. 3.0%, p = 0.54 CV death: 0.86% vs. 0.78%, p = 0.89; nonfatal cerebrovascular disease: 1.65% vs. 1.64%, p = 0.78; nonfatal MI: 0.3% vs. 0.6%, p = 0.019; TIA: 0.26% vs. 0.49%, p = 0.044Serious extracranial hemorrhage: 0.86% vs. 0.51%, p = 0.004); intracranial hemorrhage: 0.07% vs. 0.07% Trial design: Japanese patients with atherosclerotic risk factors were randomized 1:1 to receive enteric-coated aspirin 100 mg once daily or no aspirin in addition to usual care. They were followed for 5 years. Results Conclusions Ikeda Y, et al. JAMA 2014;312:2510-20 Aspirin(n = 7,323) Primary endpoint Low-dose enteric-coated aspirin is not superior to no aspirin in reducing CV events as a primary prevention strategy in elderly Japanese subjectsThere were modest reductions in the risk of nonfatal MI and TIA, but this was tempered by an increase in extracranial bleeding including GI bleeding and numerous other GI side effects % ( p = 0.54 )