PPT-The application of phenotype and environment

ontologies to Natural History Collections Rutger Vos The NBC natural history collection Naturalis is the keeper of the Dutch national natural history collection which holds approximately 37 million specimens and thereby places in the global top 5 by size. Today’s objective:. Define each evolutionary mechanism and identify which is taking place in a given scenario.. CQ: Evolution results in a better match of an organism and the environment?. Yes. No . Review. Why is genetics important?. Genetics. -the study of how genes bring about characteristics (traits) in living things and how those traits are inherited . Genes. Portions of DNA molecules that determine characteristics of living things. Beyond alleles: quantitative genetics and the evolution of phenotypes. Continuous traits have a complex genetic basis. Polygenic trait:. influenced by many genetic loci. Interaction between alleles (epistasis). . Scatter plots of . MSH6. expression against the café-au-. lait. macule burden (CALM) phenotype. . The. . upper panel of plots represents the microarray experiment, and the lower panel represents . . Cell Phenotype . Correlates with Genetics, . Transcriptome. Profile, Pathologic Hallmark and Predicts Clinical Outcome in Patients with . Crohn's. Disease. Ta-Chiang . Liu, M.D., Ph.D.. Assistant Professor. Michelle Simon and Ann-Marie Mallon . Introduction. Introduction – EUMODIC. EuroPhenome. (. www.europhenome.org. ). EMPRESS (. European Mouse . Phenotyping. Resource of Standardised Screens) . ). and plant phenotypes. George . Gkoutos. Phenotype And Trait Ontology (PATO). The meaningful cross . species and across domain . translation of phenotype is essential .  . phenotype-driven gene function discovery and comparative pathobiology . . Inheritance. . Review. . Incomplete. . Inheritance. Co-dominance. . Inheritance. SBI3U. •. . When. . one. . (1). . allele. . is. . stronger. . (so. . dominant). . than. . the. . Pre 1800s – blending hypothesis. 1850s – Gregor Mendel. Pisum. . sativum. . – what makes pea good genetic model?. -. -. -. -. Pea character (gene) = . Pea trait (allele) = . self fertilization . The genotype/phenotype relationships explored by Mendel are valid but atypical. Most phenotypes are not derived from a single gene/single phenotype model.. Why?. More than two alleles often exist. Dominance of one allele over another may not be complete. La gamme de thé MORPHEE vise toute générations recherchant le sommeil paisible tant désiré et non procuré par tout types de médicaments. Essentiellement composé de feuille de morphine, ce thé vous assurera d’un rétablissement digne d’un voyage sur . Endocannabinoid(eCB). eCBs are lipid neurotransmitters, synthesized on demand. eCBs act on both cannabioid receptors (CB1 and CB2) and Transient Receptor Potential Vanilloid (TRPV) channels. Depress Glutamatergic and GABAergic synapses . Sample & Methods. . 100 index cases (IC): 87 adults and 13 children; 8 were severe forms. . Identifies variants were traced in 36 relatives. NGS panel: LDLR, APOB, PCSK9, LDLRAP1 and APOE . (. Review 8. Important Vocabulary. Gene – piece of a chromosome that codes for a trait. Trait – a specific characteristic that varies from one individual to another. You are your parents!. Dad’s chromosomes.