PPT-Cancer Genomics Cancer Genomic testing for patients with melanoma

A 38yearold Caucasian female with a history of extensive tanning bed use has a longstanding mole on the right shin A biopsy of the lesion and subsequent histology confirmed a diagnosis of a nonulcerated superficial spreading melanoma Breslow thickness 18mm pT2a. Leisha. A. . Emens. , M.D., . Ph.D. Associate Professor . of Oncology . Tumor . Immunology and Breast . Cancer . Research . Programs. Johns Hopkins University. Conflict of Interest Statement. Biosante. NHGRI strategic plan. What does the NIH think genomics should be for the next 10 years?. [Nature, Feb. 2011]. The Essence of Genomics. (according to NHGRI). Comprehensiveness. . Genomics . aims to generate complete data sets. Although relatively easy to define and measure for a genome sequence, attaining comprehensiveness can be more challenging for other targets (for example, functional genomic elements or the ‘proteome’). 1. What, in general, is a melanoma?. A tumor of melanin-forming cells (. melanocytes. from the basal layer of the epidermis.). Typically a malignant tumor associated with skin cancer, it’s the most dangerous type of skin cancer (could spread and become lethal.). Project . What is cancer?. . “Around one third of cancer deaths are due to the 5 leading behavioural and dietary risks: High body mass index, low fruit and vegetable intake, lack of exercise, tobacco use, alcohol use (WHO Cancer Webpage)”.. Precancerous . diseases. . Odessa National medical university. С. hair of Radiation Diagnostics, Therapy and Oncology . Head . of chair, prof. . Sokolov. V.N. .. Head of Oncology cycle, prof. . Bondar. Programme. and can be adapted and used for local education and training about the patient choice consent model being implemented for whole genome sequencing in the NHS Genomic Medicine Service. . Please note that this does not address . Interview with . Lauren . Segal. 15. th. March 2018. Top 5 cancers -South Africa. Breast , cervix ,Unknown Primary , Colorectal cancer and Uterus.. Breast cancer 22%. . Life time risk 1:28; white women 1:11 and black 1:51.. Melanoma • Melan (pigment-producing) cells in the epidermis. Untreated, melanoma has a high risk for metastasis. The most common clinical subtype is super�cial spreading melanoma ( Page 25 of 30 Nodular Melanoma: A Review of Pathogenesis, Presentation, Diagnosis, and Treatment; Fabio Stefano Frech, BS; Keyvan Nouri, MD, MBA Loren E Hernandez, Dr. Phillip Frost Department of Derm Notes from meeting: February 21, 2023. GOALS. Improve collaboration and documentation towards assessment and recommendations related to genetic and genomic testing in young women with breast cancer. Offer recommendations to improve value and service for the ACBCYW . Lara K. . Goudsouzian. , Ph.D.. Associate Professor of Biology. DeSales. University. Lara.goudsouzian@desales.edu. Melanoma. Melanocytes. Produce Melanin. Melanin is a dark pigment. The melanin travels in vesicles called . Laura Yarram-Smith . Solid Tumour Lead SWGLH. July 2023. https://www.nbt.nhs.uk/south-west-genomic-laboratory-hub. Part of a Genomic Medicine Service. Bristol Clinical Genetics . Peninsula Clinical Genetics. Foundation Medicine. ctDNA. is good information for somatic mutations in . mCRPC. when biopsy is not possible. lots of other data on the importance of CTCs as predictive. 93% concordance for BRCA1/2 for tissue and liquid biopsy – . South West Genomic Laboratory Hub. 23. rd. February 2023. Haem germline findings. NGS testing for MPN. TATs. SNP arrays. WGS. 2. Haem Genomics update. A number of the genes included in haem NGS panels for their somatic actionability are also cancer susceptibility genes (CSGs) in the germline setting e.g. .