PPT-Gene Mutation Mutation = change(s) in the nucleotide/base sequence of DNA; may occur due

Mutation may result in coding sequences for new amino acids in proteins or not Mutations can occur due to errors during DNA replication replicationdependent mutations Mutations can also occur independently of DNA replication . Mutations. Hollywood’s images of . mutation. Mutations. Actual Mutations . in fruit flies. What is a mutation?. A mutation is any change in a cell’s DNA. A mutation can occur in an individual gene. Gene regulation: The ability of an organism to control which genes are transcribed in response to the environment. . Mutation. Mutation: a permanent change that occurs in a cell’s DNA. . Can range from changes in a single base pair (Ex: An A instead of a C) in the coding sequence of DNA to the deletion of large pieces of chromosomes. . Updated Summer 2015. by J. D. Hendrix. Mutations: Definitions. Lethal . mutation: results in death of the cell, and therefore cannot be propagated or studied. Conditional mutation: One that is expressed only under certain environmental conditions; for example, a temperature-sensitive mutation. 6a & b. Mutations. Learning Intentions. By the end of this topic you should be able to:. (a) Mutations. Define ‘mutation’ and describe the effect of one . (. b) Single gene mutation. (Chapter 12). Presented by Dr. Laurie M. Erickson. Chair of the Department of Health Sciences. Blitstein Institute of Hebrew Theological College. Chicago, IL, USA.. 12.1-12.2 Mutations . Mutation:. any heritable change in the genetic material. Asst. Prof. Dr. . Dalya. Basil Hanna . In this lecture…... Mutation:. Gene (point) Mutation. Chromosomal Mutation. Gene Mutation . A gene mutation occurs when the nucleotide sequence of the DNA is altered and a new sequence is passed on to the offspring. The change may be either a substitution of one or a few nucleotides for others or an insertion or deletion of one or a few pairs of nucleotides. What if it’s NOT just the number?. Gene Mutations. Damaged Chromosomes . –. sometimes a portion of a gene or chromosome is lost or damaged during meiosis. Gene mutation. – a mutation that affects the gene. Rabbani, PhD. Medical Genetics. Variation. Single nucleotide polymorphism. Mutation. Deletion and insertion. Tandem repeats. dbSNP. HapMap. Human . Variome. Project. Chromosomal abnormalities. Locus. Is a natural process that changes a DNA sequence.. Mutant or Mutation – to describe something undesirable or broken.. Rarely cause death or disease. Generates new variations that can give an individual a survival advantage.. If the enzyme that converts tyrosine to melanin is defective, no melanin is produced and a genetic disease known as albinism results.. A peacock with albinism does not produce the melanin needed to make the bright colors of its feathers.. Is a natural process that changes a DNA sequence.. As a cell copies its DNA before dividing, a “typo” occurs every 100,000 or so nucleotides.. That’s about 120,000 typos each time one of our cells divides.. that lead to . different traits . arising.  . These mutations can be passed down genetically and either be . lost. or become . fixed. .  . Since mutation usually affects a single individual in a population, the initial fraction is small and the probability of fixation is thus also small (high probability of loss).  . Warm up . What are the different types of mutations? How are mutations related to evolution?. Place your warm up in the center of the table.. Place your Lab Evidence Packet (with the essay rubric) in the center of the table.. Origami Extra Credit (15 minutes). Review DNA replication and quiz each other. - Can you answer: What is it? Where does it take place? When does it happen? Why does it happen? Can you name and identify all of the structural components of DNA (deoxyribose sugar, phosphate, hydrogen bonds, bases/nucleotides: ATCG)?.