PPT-Switch from TDF to TAF

GSUS2920109 Study GSUS3111089 Study Design Endpoints Primary proportion of patients maintaining HIV RNA lt 50 cmL at W48 ITT snapshot noninferiority if lower margin of a twosided 95 CI for the difference 10 gt 95 power. M Harris, . S Guillemi. , K Chan, B Yip. ,. . M Hull, V Dias Lima, R Hogg, J . Montaner. Abstract #: WEAB0202. Organ Dysfunction in HIV: It's . Complicated. Wednesday, 3 July 2013 14:30-16:. 00. Session . from. TDF to TAF. GS-US-292-0109 Study. GS-US-311-1089 Study. . Design. Endpoints. Primary: proportion of patients maintaining HIV RNA < 50 c/mL at W48 (ITT, snapshot) ; non-inferiority if lower margin of a two-sided 95% CI for the difference = -10%, > 95% power. STRATEGY-PI . Study. STRATEGY-NNRTI . Study. Design. Endpoints. Primary: proportion of patients maintaining HIV RNA < 50 c/mL at W48 (mITT, snapshot) ; non-inferiority if lower margin of a two-sided 95% CI for the difference = -12%, 85% power. If non-inferiority and lower margin > 0, assessment for superiority. Brian R. Wood, MD. Assistant Professor of Medicine, University of Washington. Medical Director, Frontier AETC ECHO. October 2015. ID Week Review 2015. 1) Switching from TDF to TAF. 2) Simplifying salvage therapy to E/C/F/TAF + DRV. Massachusetts General Hospital. Boston, Massachusetts. State-of-the-ART in Antiretroviral Therapy: Optimal Initial Regimens in 2016. Washington, DC: August 23, 2016. Thanks to Alice Pau, Roger Bedimo and Marilyn Shi for assistance with slides. Estudio GS-US-311-1089 . Estudio GS-US-366-1216 . Estudio GS-US-366-1160 . . Diseño. Endpoints. Primario: proporción de pacientes . con C. V . < 50 c/mL a S48 (ITT, . snapshot. ) ; no inferioridad si el margen inferior de IC95% de dos colas para la diferencia = - 8%, poder 85%. Progressive rises in weight and clinical obesity for TAF/FTC+DTG and TDF/FTC+DTG versus TDF/FTC/EFV: ADVANCE and NAMSAL trials Andrew Hill, Francois Venter, Eric Delaporte , Simiso Sokhela, Charles Medical Director, Specialty . Services. Southwest CARE Center. Santa Fe, New Mexico. State-of-the-ART. . in . Antiretroviral . Management. FORMATTED: MM/DD/YY. New Orleans, Louisiana: December 15-17, 2015. Heathland ingWoodland ingRoom ypeSundewHazelOrchidBirchGorseHollyBrackenAshHeatherOakMossBeech4/5 Bedded Pupil RoomSundewOrchidEXITSOUTHGorseBrackenHeatherMossEntranceLibraryAshHollyBirchHazelOakBeech www.hivguidelines.org. Purpose of . This Guideline. Provide a clear and concise roadmap for clinicians to follow in choosing from among several equally efficacious ART regimens based on individual patient characteristics and preferences.. Kaiser Permanente San Francisco Medical Center. San Francisco, CA, USA. Disclosure:. THE PHASE 3 DISCOVER STUDY: DAILY F/TAF OR F/TDF FOR HIV PREEXPOSURE PROPHYLAXIS. Co-Authors. Brad Hare. 1. , Pep Coll. Tenofovir. . Alafenamide. . vs. . Tenofovir. . Disoproxil. . Fumarate. Combined Safety Results of . Studies GS-US-292-0104 and GS-US-292-0111. Paul Sax. 1. , Michael Saag. 2. , Michael Yin. 3. , Frank Post. Study GS-366-1216. Switch from TDF to TAF, each with RPV and FTC. Study GS-366-1216: Design. Source: . Orkin. C et al. Lancet HIV. 2017;4:e195-e204.. *. NOTE. :. of 632 participants randomized, 2 were never treated (630 individuals treated). ROCKET-1 Trial. Switch from EFV + ABC-3TC to EFV-TDF-FTC. ROCKET-1: Design. Source: Moyle GJ, et al. . PLoS. One. 2015;10:e0116297.. Immediate switch arm. EFV-TDF-FTC. . (n = 79). Delayed switch arm .