PPT-Genomic Screening of the General Population

Michael Adams 1 James Evans 1 Gail Henderson 2 Jonathan S Berg 1 1 Department of Genetics UNCChapel Hill 2 Department of Social Medicine UNCChapel Hill Introduction Genomic screening of the general population for preventable monogenic disease has potential to decrease morbidity and . Zhicong Huang, Erman Ayday, Jacques Fellay, Jean-Pierre Hubaux, Ari Juels. Presented by Chuong Ngo. The Genomic Future. The Genomic Future. The Genomic Future. The Genomic Future. The Genomic Future. Steven Zhao PGY2. Cost Conscious Project May 2016. What is the evidence behind screening?. Screening tests should:. Be highly sensitive. Be relatively cheap/noninvasive. Identify a condition that is relatively prevalent in the population with high morbidity/mortality. Genomic Medicine. In announcing on June 26, 2000, that the first draft of the human genome had been achieved, President Clinton said it would “revolutionize the diagnosis, prevention and treatment of most, if not all, human diseases.”. National Human Genome Research Institute. National Institutes of Health. U.S. Department of Health and Human Services. U.S. Department of Health and Human Services. National Institutes of Health. National Human Genome Research Institute. Genotypes are Useful for More Than Genomic Evaluation Uses for genotypes Ancestor discovery within breeds Inheritance tracking for chromosomes Mating programs Genomic inbreeding, dominance Fertility defects – haplotypes and QTLs ForewordOne secret weapon has helped beat every disease outbreak over the last century but it is not masks or social distancing lockdowns or even vaccines Instead it is data Data tells us which masks (Abstract 58). J.B. Cole. 1,*. K.L. Parker Gaddis. 2. , C. Willard. 1. , D.J. Null. 1. , C. Maltecca. 3. , and J.S. Clay. 4. 1 . Animal Genomics and Improvement Laboratory, ARS, USDA, Beltsville, MD, USA. subtype of. . pediatric. acute lymphoblastic . leukemia. Ingegerd Ivanov Öfverholm. , . MD, PhD. Dept of Molecular Medicine and Surgery. Clinical Genetics unit. Karolinska. . Institutet. Acute lymphoblastic leukemia (ALL) - most common form of pediatric cancer. Dina Paltoo, Ph.D., M.P.H.. NIH Office of Science Policy. Laura Lyman Rodriguez, Ph.D.. National Human Genome Research Institute. October 4, 2017. Housekeeping. Participants must register to join the webinar. Chuanyu Sun. 1. , Paul M. VanRaden. 2. , Jeff R. O'Connell. 3. 1 . National Association of Animal Breeders, USA, Columbia, MO;. 2 . Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD, USA. . Rachel Butler, Head of Bristol Genetics Laboratory. National delivery of 100,000 . Genomes . P. roject. A remarkable achievement. Genomic Laboratory Hubs. South West Genomic Laboratory Hub (SWGLH). Partnership . post 100,000 . Genomes . Project. Update . – Haem SSG . Nov 2018. Contents. Genetics and genomics. Background to 100,000 Genomes Project. Project progress. What next? Mainstreaming Genomic Medicine. VOLUME 2


  
  Anuj Kumar and Michael Snyder FUNCTIONAL GENOMICSThe development andsystematic application ofexperimental methodologies toanalyse gene function on agenome-wide Dr. Breno Fragomeni. Assistant Professor. Animal Science - UConn. Where are the labels?. Introduction . Why genomic prediction?. Higher accuracy. Shorter generation interval . Higher genetic gain. Genetic gain per year.