PPT-An Immunoinformatics analysis and structure based modeling of potential HLA class II allele

Pawan Sharma Assistant Professor Mangalayatan University India Japanese encephalitis virus JEV is a flavivirus family Flaviviridea Causes disease to human beings Japanese Encephalitis JE . A model is an abstraction of reality. No model can include all the complexity of the real world. Hopefully a model includes enough complexity from the real world to adequately represent the system.. Structure-. based computer-aided drug . discovery (SB. -CADD) . approach:. helps to design and evaluate the quality, . in terms of affinity. , of series of ligands. .. Computational Methods in Drug Discovery. two different aims, one common goal provide the best protein-ligand . data. James B. Dunbar Jr. and Heather A. Carlson. 5th . Meeting on U.S. Government Chemical Databases and Open Chemistry. August 25. . Department . of Pathology & Laboratory . Medicine. Human . Leukocyte . Antigen (HLA) . complex allows the body to distinguish between . its . own proteins and the proteins of foreign invaders. Located on chromosome 6 in humans, the study of HLA is essential in organ transplantation.. Methodology Effect of Collagen Fiber Structure on Cell-Matrix Interactions Benjamin Albert 1 , Jeffrey Tonniges 2 , Gunjan Agarwal 1,3 1 Biomedical Engineering, 2 Biophysics, The Ohio State University, INTRODUCTION TO NUMERICAL MODELING IN GEOTECHNICAL ENGINEERING WITH EMPHASIS ON FLAC MODELING www.zamiran.net By Siavash Zamiran, Ph.D., P.E. Geotechnical Engineer, Marino Engineering Associates, Inc. The same physics that leads to collectivity, lowering collective states, . also . increases the binding and affects masses. That has long been known.. What . may. be new is the magnitude of the effect on masses in models such as the IBA. On . :. Challenges and Opportunities in the era of Precision Medicine. Dr. Paul . Keown, . 2016. Statement of Conflict & Collaboration. Therapeutics collaborations. Novartis, Roche, . Astellas. , Shire. GPCR FAMILY. CLASS A STRUCTURAL ANALYSIS. TASTE RECEPTORS. CONCLUSIONS & QUESTIONS. GPCRS. OVERVIEW . Also known as. 7TM receptors. Largest family of proteins in the human genome (Nearly 1000 such receptors are though to be present ). Importance of HLA in solid organ transplantation. Overview of HLA typing and histocompatibility testing in solid organ transplantation. HLA testing in solid organ transplantation. Dr. Robert Liwski, MD, PhD, FRCPC. Histocompatibility Committee. 2. What . p. roblem will the proposal solve? . Incorrectly entered HLA data in UNet is a patient safety risk. E. xample: A23 instead of A32. Creates system inefficiencies . Issues. for . Immunogenetic. . Data. Richard M. Single. Associate Professor of Statistics. Department of Mathematics & Statistics. University of Vermont. HLA . nomenclature: Why it matters for analysis and interpretation. Complex, MHC 1 Ning Pan Department of Pathogen biology and Immunology Medical School , Southeast University 2 • George Snell ( 1903 - 1996 ) discovered the first components of the MHC through their . molecules. , . their. . structure. , and . function. .. HLA . system. , 2nd . class. . molecules. , . their. . structure. , and . function. .. HLA . system. , . genetic. background. HLA . typing.