PPT-CAR T Cells in non-Hodgkin lymphoma (NHL)

Jean Koff MD MSc July 20 2023 disclosures Research funding Oncternal Therapeutics Viracta Therapeutics Atara Biotherapeutics Consulting fees Janssen Pharmacyclics MorphoSys. Rob Corbett. NCCN. Christchurch. Hodgkin Lymphoma. Great success story!. LMIC. >50% 0-10yrs old. Striking male predominance. Symptoms. 60% < 6months. B symptoms 40%. Wt. loss. Fever. Night sweats. and their . precursor . cells. .  The name often refers to just the . cancerous. . ones . rather than all such . tumors. .. Many lymphomas are known to be due to specific genetic mutations.. 3. rd. lecture 3. Lecturer . Dr.Mohanad Al-Hindawi. MBCHB, MSc. Histopathology, . CABHS.Anatomical. pathology. Non-Hodgkin lymphoma-Clinical . features . Two thirds of NHLs and . (virtually all Hodgkin lymphomas) . Basics. Lymphoma – a cancer started in the cells of the immune system. 5 types:. Hodgkin Disease. Non-Hodgkin Lymphoma. Non-Hodgkin Lymphoma in Children. Lymphoma of the Skin. Waldenstrom. . Macroglobulinemia. . Assistant Professor :. Dr.Maysem. . Mouayad. . Alwash. . . . Lymphocytes are the immunologically competent cells that assist the phagocytes in . defence. of the body against infection and other foreign invasion.. VCR VOICE Hodgkin Lymphoma (HL): most common sites are in the chest, neck, or under the arms. Hodgkin lymphoma most o�en spreads through the lymph vessels from lymph node to lymph node. Ra How to cite: Kusminsky G, Abriata G, Forman D, Sierra MS (2016).Etiology of Hodgkin lymphoma (C81) in Central and South America.In: Cancer in Central and South America.Lyon: International Agency for What is Hodgkin lymphoma? CANCER CARE Lymph nodes Lymphoma refers to a group of cancers that come from a specic group of white blood cells inside your body. ese cells are called lymphocyt About Indolent Lymphoma Non-Hodgkin’s lymphoma (NHL) is a cancer that starts in white blood cells called lymphocytes, which are part of the body’s immune system. 1 Types of NHL can be g What is Non-Hodgkin lymphoma? CANCER CARE Lymph nodes Lymphoma refers to a group of cancers that come from a specic group of white blood cells inside your body. ese cells are called lymph 1 Department of Pathology and Hematopathology, St. Jude Children's Research Hospital, Memphis, TN;Department of Pathology, Division of Hematopathology, University of Miami, Sylvester Comprehensive Can lymph nodes . Tonsils and adenoids (Waldeyer's ring) . Peyer's patches and appendix . White pulp of the spleen . Lymphadenopathy :. Localized (e.g., infection) or generalized (Systemic disease). . May be due to inflammatory, reactive or neoplastic disorders. NCCN. Christchurch. Hodgkin Lymphoma. Great success story!. LMIC. >50% 0-10yrs old. Striking male predominance. Symptoms. 60% < 6months. B symptoms 40%. Wt. loss. Fever. Night sweats. Staging. JR2 Medicine. Malignancy of mature B lymphocytes;. Represents ~ 10% of all lymphomas diagnosed each year.. Formerly called Hodgkin's disease.