PPT-Switch to Etravirine from Efavirenz due to CNS Toxicity

SSAT029 STUDY Switch to Etravirine from Efavirenz Due to CNS Toxicity SSAT029 Design Source Waters L et al AIDS 2011256571 Immediate Switch Arm Etravirine 2NRTI n 20. CNS depressants . LAB 2. Some Drugs That Effect CNS. Stimulants. Depressants. A . stimulant. is a drug that speeds up activities of the CNS. A . depressant. . is a. . drug that slows brain and body reactions. and . risks. for . human. . health. of . nanomaterials. Anne Braun. Head of the . Experimental. . Toxicology. Unit. INERIS Institut National de l’Environnement industriel et des . RISques. (National Institute for . Rachel Garvin, MD. Assistant Professor, . Neurocritical. Care. Department of Neurosurgery. Objectives. Describe critical care myopathy and neuropathy, causes, diagnosis and management. Describe CNS infections, diagnosis and management. Chapter 6. Why are CNS depressants problematic?. Usually prescribed under physician direction. Second most frequently abused prescription drug and sometimes contributes to death due to accidental overdoses. Brian Andrews. . Feedback and Improvement Manager. Consolidated Nuclear Security, LLC . Brian.Andrews@cns.doe.gov. Amanda Crumby. 10/22/2015. 1. Lessons Learned Team . FI&S . . Sharon Chamblee. 2. US National Institutes of Health, . National Library of Medicine (NIH/NLM). on-line . Toxicology Course. I. Basics. II. Toxicokinetics. III. Cellular Toxicology. http://sis.nlm.nih.gov/enviro/toxtutor.html. LAB 2. Some Drugs That Effect CNS. Stimulants. Depressants. A . stimulant. is a drug that speeds up activities of the CNS. A . depressant. . is a. . drug that slows brain and body reactions. Stimulants increase. Dr. . . Kumari. . Anjana. Assistant Professor. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. C N S . stimulants. Central nervous system stimulants are drugs that . 1 2 CSFFormed at choroid plexuses in the ventriclesCushioning effectNormal: 10 mmHg in pressure, 1.002 1.009 in SG, 7.32 in pHncreased productiondecreased absorption, and/orobstruction of flow ofCSF a 4. th. Stage . Dr. Dalia . Abd. Al- Kader. PhD Pharmacology. Sympathomimetics. are stimulants that mimic the sympathetic nervous system.. produce a relative increase of adrenergic neurotransmitters at their sites of action. From PNS to CNS. From CNS to PNS. Skeletal muscle . smooth muscle, cardiac muscle, and glands. The main function is to connect CNS to the limbs and organs.. Consists : . A- nerves . B- ganglia . 4. th. stage. Lec. . . 2 . CNS Stimulants. A type of drug that increases the levels of certain chemicals in the brain and . increases. . alertness. , . attention. , . energy. , and . physical activity. ADONE Trial. Simplification to Efavirenz-Tenofovir DF-Emtricitabine . ADONE: Study Design. Source: . Airoldi. M, et al. Patient Prefer Adherence. 2010;4:115-25.. Study Design: ADONE Study . Background. SWEET Trial . Switch to Efavirenz + TDF-FTC . SWEET: Study Design. Source: Fisher M, et al. . J Acquir Immune Defic Syndr. 2009;51:562-8.. Background. : Randomized, . controlled, open-label, phase 3 trial evaluating a simplification strategy for patients suppressed .