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Current and Emerging Treatments for IBD Current and Emerging Treatments for IBD

Current and Emerging Treatments for IBD - PowerPoint Presentation

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Uploaded On 2018-09-21

Current and Emerging Treatments for IBD - PPT Presentation

This program will include a discussion of investigational agents not approved by the FDA for use in the United States IBD Background Evolving Treatment Landscape in IBD Limitations of Current IBD Therapies ID: 674313

severe study ibd moderate study severe moderate ibd results phase octave therapies emerging efficacy anti fitzroy etrolizumab inhibitors abrilumab treatment modulators s1p

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Presentation Transcript

Slide1

Current and Emerging Treatments for IBDSlide2
Slide3

This program will include a discussion of

investigational agents not approved by the FDA for use in the United States. Slide4

IBD BackgroundSlide5

Evolving Treatment Landscape in IBDSlide6

Limitations of Current IBD TherapiesSlide7

Investigational Therapies: MOAsSlide8

Anti-Integrin TherapiesSlide9

Selective Adhesion Molecule InhibitorsSlide10

Etrolizumab in Moderate to Severe UC

Phase 2 StudySlide11

Etrolizumab in Moderate to Severe UC

Phase 2 Study ResultsSlide12

Abrilumab in Moderate to Severe UC

Phase 2b StudySlide13

Abrilumab in Moderate to Severe UC

Phase 2b Study ResultsSlide14

PF-00547659 Anti-MAdCAM-1 Antibody TURANDOT StudySlide15

S1P Receptor ModulatorsSlide16

S1P Receptor Modulators (cont)Slide17

Ozanimod in Moderate to Severe UC TOUCHSTONE StudySlide18

TOUCHSTONE Efficacy ResultsSlide19

Emerging Anti-Interleukin mAbs in IBDSlide20

Ustekinumab for IBDSlide21

Risankizumab in Moderate to Severe CD

Phase 2 StudySlide22

Risankizumab in Moderate to Severe CD

Phase 2 Study ResultsSlide23

Brazikumab in Moderate to Severe CD

Phase 2a StudySlide24

Mirikizumab in IBDSlide25

JAK InhibitorsSlide26

OCTAVE Trials: Tofacitinib in UCSlide27

OCTAVE 1 and 2 Efficacy ResultsSlide28

OCTAVE Sustain Efficacy ResultsSlide29

OCTAVE: Efficacy by Prior TNF Inhibitor ExposureSlide30

OCTAVE: Adverse EventsSlide31

Filgotinib in Moderate to Severe CD

FITZROY StudySlide32

Filgotinib in Moderate to Severe CD

FITZROY Study ResultsSlide33

Upadacitinib in Moderate to Severe CD

Celest StudySlide34

Upadacitinib in Moderate to Severe CD

Celest Study ResultsSlide35

Other Emerging Therapies

RifaximinSlide36

Other Emerging Therapies in IBDSlide37

Possibilities for Future Treatment in IBDSlide38

AbbreviationsSlide39

Abbreviations (cont)