PPT-Motif discovery GENOME 559: Introduction to Statistical and Computational Genomics

Prof William Stafford Noble Stuff folks liked Good pace x3 Powerpoint was easy to follow x2 Really appreciate reading the program step by step x2 Helpful to go over the sample problems at the beginning of class. NHGRI strategic plan. What does the NIH think genomics should be for the next 10 years?. [Nature, Feb. 2011]. The Essence of Genomics. (according to NHGRI). Comprehensiveness. . Genomics . aims to generate complete data sets. Although relatively easy to define and measure for a genome sequence, attaining comprehensiveness can be more challenging for other targets (for example, functional genomic elements or the ‘proteome’). (B) . Amplification and detection . of DNA . sequences. . (A) Sequencing DNA. DNA. Human Genomics . (A). State what the Human Genome Project involved. State what is meant by ‘bioinformatics’. State 2 benefits of using computer technology.  . I. Genetic, Cytological, and Physical Maps. II. Human Genome Project. A. . Goals of the Human Genome Project. B. . Public and Private First Drafts of the Human Genome Sequence. Prof. William Stafford Noble. for. . loop review. block of code. for <element> in <object>:. <statement>. <statement>. . . .. <last statement>. . <element>. is a newly created variable name. You . selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Goal: A systems-level understanding of genomes and gene regulation:. Overview and Capabilities: . . High Throughput Sequencing Facility (HTSG). Functional Genomics M. ammalian Genotyping Core (MGC). Corbin Jones. Faculty Director. Piotr . Meiczkowski . Technologies . Leming. Zhou, PhD. Assistant Professor. Department of Health Information Management . School of Health and Rehabilitation . Sciences. University of Pittsburgh. Human Genome Project. 1990 – 2003. Goals:. Motif 4. Motif 4. Motif 5. Motif 6. Supplementary . Figure . S2. . Amino acid sequence alignment of the five members of the Arabidopsis PAR1-family proteins (LAT1-5) shows a number of conserved regions and motifs throughout the protein sequence. Motifs were identified using Multiple . Genomics and Society Nature (2014) “ …disorders not readily explained by standard tests can sometimes be diagnosed through genome sequencing and analysis.” The Origin of “Genomics& from NHGRI’s . Planning . Workshop on the Future Opportunities . for . Genome Sequencing . & Beyond. Mark Gerstein & Rick Myers. Recommendations related to genome function. . Part 1: Workshop summary (Mark). Bionano Genomics, San Diego, California, United States of America. Abstract. Pat Lynch, PhD. Background. Generating high-quality finished genomes replete with accurate identification of structural variation and high completion (minimal gaps) remains challenging using short read sequencing technologies alone. The . . . Shawneequa L. Callier, JD, MA . Associate Professor. Clinical Research and Leadership. School of Medicine and Health Sciences. George Washington University. Special Volunteer. Center for Research on Genomics . Bella Starling. Director of Public . Programmes. , CMFT. Wellcome. Trust Engagement Fellow. About me. Career. Scientist (neuroscience, genetics, stem cells). Science writer. Biomedical ethics. Public engagement, . Ian Green. Clinical Engagement and Education Business Manager. Strategy. Work undertaken by Genome One (part of the . Garvan. Institute). Work underway. Completion date . –. 17. th. , March 2017.