Biology 100 December 2013 By Mary Hubert Introduction In this area of science regeneration scientists along with researchers are successfully regenerating fingertip for people as well as preparing for and are hopeful to do the same for skin on other limbs and even internal organs This r ID: 499515
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Slide1
Stem Cells regenerate new finger!
Biology 100December 2013By: Mary HubertSlide2
Introduction
In this area of science, regeneration, scientists along with researchers are successfully regenerating fingertip for people as well as preparing for and are hopeful to do the same for skin on other limbs and even internal organs. This regrowth process is made possible from a tissue found in pig bladder. They have found success in combining this pig bladder tissue with a connective tissue, to make what is called extracellular matrix (ECM). What happens is the ECM jump starts the body to regrow. This ECM changes the body's thinking from fixing inflamed or injured cells to instead regrow them. Researchers are hopeful that they can eventually, successfully, regrow entire limbs. Along with researchers and doctors, the U.S. military has invested millions into this project to hopefully help injured soldiers regain lost limbs, muscle and burnt skin.Slide3
Statement/Hypothesis
What happens is the ECM jump starts the body in telling it to regrow, as opposed to fixing inflamed or injured
cells.Slide4
Materials
Pig bladder (in powder form)
Connective
tissue
Broken/lost
skin, muscle or
arterie
Clinical/surgical
toolsSlide5
Methods/Clinical Trials
Spray
on own
patient’s
cells onto a burn to signal the skin to start regrowth (currently being done in Germany
).
Conforming
a tube made of ECM
(
http://
onlinelibrary.wiley.com/doi/10.1002/ar.b.20081
/full
)
to
insert into
patients with throat
cancer
.
A
bandage type material constructed of ECM to act as a band aid to fix people's
damaged
arterie
tissue
that resulted from a heart
attack
Actual
trial: A woman underwent
surgery,
she was injected with her own (adult) cells into certain regions of her heart to regrow her arteries and tissue.Slide6
Results
If surgery outcomes are successful, and new cells can be grown via ECM then "...there will be less need for surgery"
(
Mary Jo
Babo
).
Lee
Speevak’s
finger tip was completely regrown in four weeks with ECM so researchers are dreaming of the day when regenerated limbs will replace prosthetic limbs, regrown tissue replaces surgery, when the body
does
its healing from the cells from within
().Slide7
Discussion
AS research expands, we are seeing that animals aren’tthe butt of it anymore. The outcomes of Speevak’s
and
Babo’s
medical miracles gives hope to more and more
People, like
Babo
mentioned in the CBS News video.
The fact that doctors and researchers are innovating
new tools to help heal patients with cancer, burns,
autonomy and tissue damage is amazing to be able to
w
itness. Slide8
Scientific Pathways
Scientists are using members of the community like
Speevak
And
Babo
to test their hypothesis on ECM. They are also collaborating with doctors and other medical professionals and labs and universities to gain opinions and ideas and to explore, discover, communicate and apply for succession. While utilizing community members and professionals for answers and ideas, researchers also undergo significant trial and error as they create new products and diagnoses. “The process of science involves testing ideas about the natural world with data from the natural world”-Lucy
LoydSlide9
Sources &
Credits(video)http://www.youtube.com/watch?v=O_OI4TtzlDw
http://onlinelibrary.wiley.com/doi/10.1002/ar.b.20081
/full