PDF-Cell Dependent Immunogenicity of Protein Therapeutics

REFERENCE T Preclinical Assessment and Mitigation LP Cousens 1 V Jawa 2 M Awwad 3 E Wakshull 4 H Kropshofer 5 W Martin 1 AS De Groot 16 1 EpiVax Inc USA 2 Amgen Inc . Xiaoying Chen, . Timothy Hickling. , Paolo Vicini. PDM-NBE, Pfizer, USA. New technologies for immunogenicity assays/prediction. European Immunogenicity Platform February 23-25, 2015 . Complexity of Immunogenicity. Soma . Mukherjee. SMU,Chemistry. 5. th. April’2011. Introduction : Protein & important structural features for therapeutics.. Development. Classification. Examples of Protein as targeted delivery device. . Response occurs within days of the infection. . Highly specific. . Highly diverse. . Memory component. . Major cell types involved: T cells, B cells and antigen presenting cells. Antigens and Antibodies (CH4). Katalin. . Karikó. , . PhD. BioNTech. . RNA . Pharmaceuticals. Mainz, Germany. http://www.biontech.de. katalin.kariko@biontech.de. 7. th. EIP Congress, Lisbon. February 25, . 2015. RNA therapeutics in clinical trials. Proteolytic. Susceptibility … . Fátima. Ferreira. Department of Molecular Biology. University of Salzburg, Austria. WHAT SHAPES AN ALLERGEN. ?. The. . diversity. . and. . complexity. . of. . Celgene: . Abraxane. (nearly ~$1B per year). Paclitaxel (small molecules) associated with albumin. . 1. Molecular Engineering - Examples. Genentech: Antibody . engineering. i.e., KBI Biopharma, etc., etc. 2020Corporate PresentationMarch 2021Certaininformationsetforthinthispresentationcontainsforward-lookinginformationincludingfutureorientedfinancialinformationandfinancialoutlookunderapplicablesecuritie T-Cell Dependent Immunogenicity of Protein TherapeuticsPreclinical Assessment and MitigationLP Cousens1 V Jawa2 M Awwad3 E Wakshull4 H Kropshofer5 W Martin1 AS De Groot161EpiVax Inc USA2Amgen IncUSA 3 2020Corporate PresentationMarch 2021Certaininformationsetforthinthispresentationcontainsforward-lookinginformationincludingfutureorientedfinancialinformationandfinancialoutlookunderapplicablesecuritie By the end of this session student should be able to know. . Definition of antigen. . Factors influencing immunogenicity. Biological classes of antigens. . ANTIGEN. Defined as any substance that satisfies two distinct immunologic . Biotherapeutics. Biowaivers. and . Biosimilars. – 2014. October 27-29, 2014 . Hyderabad, India. Surendra J. Chavan, Ph.D.. CTO & Founder. Quantimmune. Solutions PVT. Subsidiary of . Accutest. Prof. Ibrahim A. . Alsarra. Professor . of . Pharmaceutics . and Pharmaceutical . Biotechnology.                                  .  . Immunogenicity. : the capability of a specific substance to induce an unwanted immune response that is triggered by more than one single factor.. Mukherjee. SMU,Chemistry. 5. th. April’2011. Introduction : Protein & important structural features for therapeutics.. Development. Classification. Examples of Protein as targeted delivery device. Protein . kinase. A . protein . kinase.  is a . kinase.  enzyme that modifies other proteins by chemically adding phosphate groups to them (. phosphorylation. ). . Phosphorylation. usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. .