PPT-Pathophysiology of Obesity: Appetite Regulation and Metabolic

A daptation Module 2 Pathophysiology of Obesity Appetite Regulation and Metabolic Adaptation Thank you for using the FORWARD Focus on Obesity Education curriculum   Novo Nordisk Inc provided funding support for the FORWARD Focus on Obesity Education curriculum A thirdparty provider developed the content in consultation with Novo Nordisk Inc and leading obesity clinician experts FORWARD relies exclusively on opensource materials available to the general public. Aaron Cheatham. Fat is just what we thought. The cause of excess subcutaneous and visceral fat deposition in an individual is the cumulative effect of an imbalance between the energy of ingested food and that expended in the course of daily activities. Chhavi Agarwal, MD, FAAP, MRCP (UK). Assistant Professor. Division of Pediatric Endocrinology. Objectives. Metabolic Syndrome. Etiology. Relationship of various components . Primary care setting- Screening for the risk factors . Prof Mary Ann Lumsden. Prof of Gynaecology and Medical Education. February 2013. Mortality Rates in Women. National Center for Health Statistics. 1999:164-167.. Coronary Artery Disease. Stroke. Lung Cancer. Obesity Pathophysiology. Obesity Has Multiple Pathophysiologic Origins. 2. Bray GA, et al. . Lancet. . 2016;387:1947-1956.. Obesity. Epigenetic. Genetic. Physiologic. Behavioral. Sociocultural. Environmental. Prevalence of Adult Obesity: 2000 to Present. Clinical Disease Linked to Obesity. Effect of Obesity on Health-related Quality-of-Life. Effects of Obesity on Mortality: Starting at Age 35 in Men. Environmental Influences on . NWAIWU. PROKINETIC AGENTS. Medications that enhance coordinated GI motility and transit in the GI tract.. Pharmacologically and chemically diverse.. NEURAL REGULATION OF GASTRIC MOTILITY. Stimulation by cholinergic neurons.. OBESITY, DYSLIPIDEMIA AND THE METABOLIC SYNDROME. Vincent Bufalino, MD. Senior Vice President – Advocate Heart Institute. Senior Medical Director of Cardiology - AMG. Evolution. 2. Age-adjusted prevalence of obesity in adults 20–74 years of age, . Fat is just what we thought. The cause of excess subcutaneous and visceral fat deposition in an individual is the cumulative effect of an imbalance between the energy of ingested food and that expended in the course of daily activities. problems. . Obesity affects not just appearance of a person but disease processes as well.. Obesity. Pharmacological . approaches to control obesity have become a prime priority. Due to unclear etiology, the cure of obesity is difficult and challenging. Current trends for obesity management involve multiple pharmacological strategies including blocking nutrient absorption, modulating fat metabolism, regulating adipose signals and modulating the satiety . B.Sc. (Ilorin), M.Sc. .. , Ph.D. (Ibadan). Department of Biochemistry,. EUI.. OUTLINE. Definition. Prevalence of MS. Diseases associated with MS. Pathophysiology of MS. :. Positive energy balance. Inflammatory . 269 flammation, Cardiovascular disease, Endothelium.IntroductionNAFLD with obesity, type 2 diabetes andNAFLD is still not clear, even if the insulin. In particular, a decreased sensi-. Moreover, a lar 1. . Metabolically unhealthy obese (MUO) individuals exhibit obesity-related metabolic abnormalities, while metabolically healthy obese (MHO) individuals do not. 2. . Controversy exists over whether the MHO classification is a transient state that occurs prior to metabolic disease development or if . Associate Professor. Department of Medicine. King George’s Medical University, . Lucknow. International Diabetes Federation Definition: . Abdominal obesity . plus. two other components. : . elevated BP, low HDL, elevated TG, or impaired fasting glucose. . Hameed. . Na. ser. . OBESITY. METABOLIC CHANGES IN OBESITY. The primary metabolic effects of obesity : dyslipidemias, glucose intolerance, insulin resistance expressed primarily in the liver, muscle, and adipose tissue. .