2019 Building the first truly comprehensive functional catalogue of a mammalian genome Systematically phenotyping 20000 knockout mouse strains one for each gene Our current database has Over 6000 genes phenotyped ID: 920140
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Slide1
International Mouse Phenotyping Consortium (IMPC)
2019
Slide2Building the first truly comprehensive, functional catalogue of a mammalian genome.
Systematically phenotyping 20,000 knockout mouse strains, one for each gene
.Our current database has:Over 6000 genes phenotyped (and growing!)All data freely available to the scientific community.Mutant strains available to order for your own research.
Creating a comprehensive catalogue of mammalian gene function.
Goals of the IMPC
www.mousephenotype.org
Slide3Discovered extensive
pleiotropy and sexual
dimorphism.Deduced that one third of genes have embryo defects and are enriched for human disease genes.Created hundreds of novel mouse models of human disease, based on phenotype match with clinical features.Published systemic analyses on MetabolismEyesightHearingMore coming….
Creating a comprehensive catalogue of mammalian gene function.
Major achievements
of the IMPC
No Sex Effect
Male Greater
Female Greater
Moore BA et
al.
Commun
Biol. 2018 Dec
21;1:236.
Rozman
J et
al.Nat
Commun
. 2018 Jan 18;9(1):288
Bowl MR et
al.Nat
Commun
. 2017 Oct 12;8(1):886
Slide4Our 10 year strategy document outlines our future plans, where we
aim to:Continue to develop strategic partnerships with global genetic disease consortia.Complete a null mouse mutant resource for the coding genomeContinue to push the state of the art in genomic engineering to create mouse models with human disease variants.Design and generate mouse strains that model variation in the non-coding genome.And much more….
Creating a comprehensive catalogue of mammalian gene function.
The IMPC’s expanding mission