PPT-REPRODUCTIVE TOXICOLOGY STUDIES

REPRODUCTIVE TOXICOLOGY STUDIES OECD GUIDELINES 422  WHAT IS REPRODUCTIVE TOXICOLOGY Reproductive toxicity refers to structural and functional alterations that affect reproductive system in sexually mature males and females. Topics for Principles of Toxicology: Part B. Endocrine Toxicity. Carcinogenicity. Neurotoxicity. Persistence and Bioaccumulation. The topics for “Part C” (what we could not cover). Summary. The systemic problem. Director In Vivo Facility Michigan State University, . Chief Development Officer Integrated Nonclinical Development Solutions (INDS) Inc.. Safety Pharmacology Endpoints: Integration into Toxicology Studies. Toxicology. Poison is any substance that can harm or . kill.. Toxicology is the study of poisons.. Forensic Toxicology . is the study of postmortem . signs of the poisoning.. Toxicology. The idea of poison came from the Greek word, “. Tracie Phillips, Ph.D. & Roberta Grant, Ph.D.. Toxicology Division. Texas Commission on Environmental Quality. Environmental Trade Fair 2015. Objectives. New Toxicology Database:. Database Introduction. The Study of Poisons. Beginning the Journey into. Toxicology. Murder Magic and Medicine. The Goals of this course. Introduce the Principles of Toxicology. Part A. History of Toxicology. Dose-response. Overview. Overview. . of. . the. . Food. . and. . Drug. . Administration. . (FDA).  . • . . Regulatory. . Agencies. . Outside. . of. . the. . United. . States.  . • . . Overview. Washington State Toxicology Lab. Washington State Patrol. Brian Capron. Laboratory Staffing Updates. New Laboratory Manger: Dr. Brianna Peterson . Two toxicologists still on maternity leave. Lisa Noble (return November). Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. Branches of . Toxicology. Hepatic Granulomas. Marusia Popovech, PhD, MPH. Senior Toxicologist, ExxonMobil Biomedical Sciences, Inc.. Member, CONCAWE STF-33 October 18, 2017. Introduction. F344 Hepatic Granuloma. Strain-Dependent Differences . Compilation of EU Dioxin Exposureand Health DataTask 8 - Human toxicologyReport produced forEuropean Commission EnvironmentUK Department of the Environment, Transport and theRegions (DETR)October 1999 Carcinogenicity. and . Teratogenicity. B.Pharm. . Sixth Sem.. BP602T. GENOTOXICITY. It is a word in genetics defined as a destructive effect on a cell's genetic material (DNA, RNA) affecting its integrity.. Tim MacLachlan, PhD, DABT. Chair. , . BioSafe . Leadership Committee. Executive Director, Biologics . Safety Assessment Preclinical . Safety, Novartis. The . opinions expressed in this presentation reflect those of the presenter(s) (or speaker(s)) only and do not . Brenda J. Gehrke, Ph.D.. Office of New Drugs/CDER/FDA. November 2016. Abbreviations. ADME. : absorption, distribution, metabolism, excretion. HU. : hydroxyurea. IB. : Investigator Brochure. ICH. : International Council for . Introduction. Toxicology is the study of adverse effects of xenobiotics in humans.. Xenobiotics—chemicals and drugs not normally found or produced in the body. .. Three major disciplines within toxicology.